Publication

[JCI Insight] To test if β1-containing integrins are required during repair following acute injury, scientists administered E. coli lipopolysaccharide (LPS) by intratracheal injection to mice with a post-developmental deletion of β1 integrin in AT2 cells. β1-deficient AT2 cells showed persistently increased proliferation after injury, which was blocked by inhibiting NF-kB activation.

[Microbiology Spectrum] Scientists compared phenotypes and proinflammatory properties of A. xylosoxidans, A. dolens, A. insuavis, and A. ruhlandii using in vitro models. Bacterial supernatants were used to stimulate cystic firbosis bronchial epithelial cells and whole blood from healthy individuals.

[Phytotherapy Research] Investigators studied the effect of magnolol on alleviating fibrosis in COPD based on transient receptor potential vanilloid 4 (TRPV4), and to further analyze its mechanism of action on TRPV4.

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Researchers demonstrated how mechanical forces generated during bronchoconstriction may suppress antiviral responses at the airway epithelium without any difference in viral replication.

[Scientific Reports] Researchers showed that fatty acid synthase (FASN) expression was significantly reduced in the lungs of idiopathic pulmonary fibrosis patients and bleomycin (BLM)-treated mice. Overexpression of FASN significantly inhibited BLM-induced alveolar epithelial cell death, which was significantly potentiated by FASN knockdown.

[Aging] To investigate the role of PZR, a transmembrane glycoprotein, in lung cancer, scientists employed the CRISPR technique to knockout its expression and recombinant lentiviruses to overexpress it in lung adenocarcinoma SPC-A1 cells.