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Human Placental Mesenchymal Stem Cell-Derived Exosomes in Combination with Hyperbaric Oxygen Synergistically Promote Recovery after Spinal Cord Injury in Rats
[Neurotoxicity Research] Scientists investigated the combined effects of human placenta MSCs-derived exosomes along with hyperbaric oxygen in the recovery of spinal cord injury in rats.
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Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-L-cysteine Stimulates Changes in Energy Metabolites and Amino Acids in the BeWo Human Placental Trophoblast Model during Syncytialization
[Chemical Research In Toxicology] Researchers investigated S-(1,2-dichlorovinyl)-l-cysteine-induced changes to energy metabolism and amino acids during forskolin-stimulated syncytialization in BeWo cells, a human villous trophoblastic cell line that modeled syncytialization in vitro.
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Human Umbilical Cord Blood Mononuclear Cells Ameliorate Ischemic Brain Injury via Promoting Microglia/Macrophages M2 Polarization in MCAO Rats
[Experimental Brain Research] The authors explored whether human umbilical cord blood mononuclear cells treatment for cerebral infarction via regulation of microglia/macrophages polarization.
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Characterization of Xenobiotic and Steroid Disposition Potential of Human Placental Tissue and Cell Lines (BeWo, JEG-3, JAR, and HTR-8/SVneo) by Quantitative Proteomics
[Drug Metabolism and Disposition] Investigators characterized the abundance of proteins involved in xenobiotic and steroid disposition in human placental tissue and compared the tissue proteomics data with four placental cell lines.
ESC & iPSC News
Directing iPSC Differentiation into iTenocytes Using Combined Scleraxis Overexpression and Cyclic Loading
[Journal Of Orthopaedic Research] The authors attempted to induce tenogenesis using stable Scleraxis (Scx) overexpression in combination with uniaxial mechanical stretch of iPSC-derived mesenchymal stromal-like cells.
Cancer Stem Cell News
Identification and Characterization of the Wilms Tumor Cancer Stem Cell
[Advanced Science] A nephrogenic progenitor cell with CSC characteristics driving Wilms tumor using spatial transcriptomics, bulk and single cell RNA sequencing, and complementary in vitro and transplantation experiments was identified and characterized.