Publication

Investigators uncovered EGFR as substrate of the E3 ubiquitin ligase FBXW7 and found multiple phosphodegron-like motifs within its intracellular domain that when mutated reduce EGFR degradation.They used CRISPR base editors to...

Investigators presented OrgaSegment, a MASK-RCNN based deep-learning segmentation model allowing for the segmentation of individual intestinal patient-derived organoids structures from bright-field images.

Scientists explored the role of dapagliflozin on WAT browning in high-fat diet (HFD)-induced obese mice. Male C57BL/6J mice were used to establish an obesity model by following feeding with HFD for...

Investigators directly reprogrammed adult human dermal fibroblasts into reprogrammed endothelial cells (ECs) by overexpressing SOX17 in conjunction with ETS variant 2 (ETV2).

Human umbilical vein endothelial cells were subjected to physiological shear stress and low shear stress treatments, followed by the application of autophagy inducers and inhibitors. Additionally, cells were treated with specific...

Scientists sought to enhance the in vivo longevity of CAR-Vδ2 T cells by modulating ex vivo manufacturing conditions and selecting an optimal CAR costimulatory domain.