Publication

[Immunity] Investigators focused on Slc46a2, which was highly expressed in mammalian epidermal keratinocytes, and showed that it was critical for the delivery of diaminopimelic acid-muropeptides and activation of NOD1 in keratinocytes.

[Journal Of Clinical Investigation] Scientists reported increased levels and activity of dipeptidyl peptidase 4 (DPP4), a serine protease, in senescent vascular smooth muscle cells.

[Nature Communications] Researchers showed that soluble pathogenic tau accumulated in brain microvascular endothelial cells of P301S mice modeling tauopathy and drove Alzheimer’s disease-like brain microvascular deficits.

[Elife] Investigators uncovered an essential role for the secreted protein pentraxin domain-containing protein 1 (Svep1) and the transmembrane receptor tyrosine-protein kinase receptor 1 (Tie1) during the development of subpopulations of the zebrafish facial lymphatic network.

[CNS Neuroscience & Therapeutics] Mice were orally administered with Tongxinluo capsule after transient middle cerebral artery occlusion. Scientists examined neurological function, no-reflow, leukocyte-endothelial cell interactions, HE staining, leukocyte subtypes, adhesion molecules, and chemokines.

[Frontiers in Cell and Developmental Biology] Immortalized lines of endothelial cells (ECs) from the same patient with breast cancer, healthy breast tissue, and primary tumor were used. The experiments were performed in normoxia and hypoxia for 48 hours.