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ADSC-Exos Enhance Functional Recovery After Spinal Cord Injury by Inhibiting Ferroptosis and Promoting the Survival and Function of Endothelial Cells Through the NRF2/SLC7A11/GPX4 Pathway

[Biomedicine & Pharmacotherapy] Researchers investigated the potential mechanisms of exosomes from adipose-derived stem cells (ADSC-Exos) in reducing ferroptosis and promoting angiogenesis after spinal cord injury.

Long Non-Coding RNA H19X as a Regulator of Mononuclear Cell Adhesion to the Endothelium in Systemic Sclerosis

[Rheumatology] Investigators defined the functional relevance of H19 X-linked co-expressed lncRNA (H19X) in endothelial cell activation as a key process in systemic sclerosis vasculopathy.

α7nAChR Activation Combined with Endothelial Progenitor Cell Transplantation Attenuates Lung Injury in Diabetic Rats with Sepsis Through the NF-κB Pathway

[Inflammation] Lung injury caused by sepsis was compared between diabetic rats and normal rats. Scientists examined whether α7 nicotinic acetylcholine receptor (α7nAChR) activation combined with endothelial progenitor cell transplantation could ameliorate lung injury in diabetic sepsis rats.

Mesenchymal Stem Cells Inhibit Ferroptosis by Activating the Nrf2 Antioxidation Pathway in Severe Acute Pancreatitis-Associated Acute Lung Injury

[European Journal Of Pharmacology] Scientists investigated the protective effects of MSCs against aevere acute pancreatitis-associated acute lung injury and its underlying mechanisms. Their results suggest that MSCs mitigate pathological injury, hemorrhage, edema, inflammatory response in lung tissue, and lipopolysaccharide-induced cell damage in RLE-6TN cells.

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Pretreated by Monosialoteterahexosyl Ganglioside Alleviate Intracerebral Hemorrhage by Down-Regulating Autophagy

[Experimental Cell Research] In vitro, human umbilical cord mesenchymal stem cells were cultured and induced to differentiate into neuron-like cells after they were pretreated with 150 μg/mL monosialoteterahexosyl ganglioside.

Mesenchymal Stromal/Stem Cells (MSCs) Know Best: The Remarkable Complexities of Its Interactions with Polymorphonuclear Neutrophils (PMNs)

[Stem Cells] Researchers highlighted the intricate interplay between PMNs and MSCs and their profound relevance in healthy and pathological conditions, shedding light on how to best strategize the use of MSCs in the expanding list of diseases with PMN involvement.

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