Publication

[Cancer Immunology Research] Researchers studied the effects of anti-CTLA-4 when combined with anti-PD1 and gemcitabine/cisplatin in orthotopic murine models of intrahepatic cholangiocarcinoma.

[Inflammation Research] The model of rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLSs) overexpressing mammalian STE20-like kinase 1 (MST1) was constructed by lentiviral transfection in vitro and analyzed the effects of MST1 on apoptosis, migration, invasion, and inflammation of RA-FLSs.

[Journal Of Immunology] Investigators examined whether Cullin-RING E3 ubiquitin ligase 4b (CRL4b) was required for T cells to expand and drive encephalomyelitis (EAE). Mice lacking Cullin 4b in T cells had reduced EAE symptoms and decreased inflammation during the peak of the disease.

[Science Translational Medicine] This phase I study investigated the safety and efficacy of pexidartinib, a CSF-1R–directed tyrosine kinase inhibitor, and durvalumab in patients with advanced colorectal and pancreatic carcinoma with the aim to enhance responses to PD-L1 blockade by eliminating CSF-1–dependent suppressive tumor-associated macrophage.

[Glia] Microglia were successfully differentiated from retinoblastoma patient- derived human induced pluripotent stem cells and human embryonic stem cells, and investigated the function of RB1 in microglia by live imaging phagocytosis assay, immunofluorescence, RNA-seq, qRT-PCR, ELISA and retina organoids/microglia co-culturing.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists performed an unbiased proteomic analysis and identified a fibronectin-derived peptide called Anastellin that was unique to the tissue inhibitor of metalloproteinase-1 (TIMP1) knockout astrocyte secretome.