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Single-Cell RNA Sequencing Reveals Association of Aberrant Placental Trophoblasts and FN1 Reduction in Late-Onset Fetal Growth Restriction

[Placenta] Single-cell RNA sequencing was performed on the maternal side of placentas from two normal pregnant women and two pregnant women with FGR. Lentivirus transfection was used to establish a FN1 knockout model in trophoblast HTR-8-Svneo cells.

Prognostic Impact and Immunotherapeutic Implications of NETosis-Related Gene Signature in Gastric Cancer Patients

[Journal Of Cellular And Molecular Medicine] The authors explored the biological enrichment difference between high- and low-risk patients and found that many carcinogenic pathways were upregulated in the high-risk patients.

INO80-Dependent Remodeling of Transcriptional Regulatory Network Underlies the Progression of Heart Failure

[Circulation] The authors integrated human samples, genetic mouse models, and genomic approaches to identify the role of chromatin remodeling complex INO80 in heart homeostasis and dysfunction.

OTUD1 Promotes Isoprenaline- and Myocardial Infarction-Induced Heart Failure by Targeting PDE5A in Cardiomyocytes

[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] Researchers investigated the role of the ovarian tumor deubiquitinase 1 (OTUD1) in isoprenaline- and myocardial infarction-induced heart failure and its molecular mechanism.

Predicting Myosin Heavy Chain Isoform from Post-Dissection Fiber Length in Human Skeletal Muscle Fibers

[American Journal Of Physiology-Cell Physiology] Researchers measured normalized fiber length, expressed as a % of length of the bundle from which the fiber was dissected, in single fibers immediately following dissection. 668 individual fibers were dissected from muscle tissue samples from healthy, young adults.

Myopathy-Causing Mutation R91P in the TPM3 Gene Drastically Impairs Structural and Functional Properties of Slow Skeletal Muscle Tropomyosin γβ-Heterodimer

[Archives of Biochemistry and Biophysics] The authors investigated the influence of the R91P mutation in the γ-chain on the properties of the γβ-tropomyosin heterodimer.

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