Publication

[Cell Metabolism] Investigators found that deficiency in tumor glycolysis activated a metabolic switch from glycolysis to fatty acid β-oxidationto fuel TNBC growth. They showed that, in TNBC cells, PKM2 directly interacts with histone methyltransferase EZH2 to coordinately mediate epigenetic silencing of a carnitine transporter, SLC16A9.

[Cell Reports] Scientists show edthat lactogenic differentiation of murine mammary epithelial cells requires silencing of genes encoding ribosomal RNA (rRNA) by the antisense transcript PAPAS.

[NPJ Breast Cancer] Researchers qualified a breast cancer-specific antibody panel, including HER2, ER, and PR, for multiplexed tissue imaging. They then compared the performance of these antibodies against established clinical standards using pixel-, cell- and tissue-level analyses, utilizing 866 tissue cores

[European Journal Of Clinical Investigation] Scientists showed that gasdermin C sensitized tumor cells to several poly (ADP-ribose) polymerase inhibitors in vitro and in immunocompetent mice and caused durable tumor regression in an immune-dependent manner.

[European Journal Of Nuclear Medicine And Molecular Imaging] Aflibercept was radiolabeled with 89Zr and 177Lu via the conjugation of chelators. Flow cytometry and cell immunofluorescent staining were performed to evaluate the binding affinity of Abe.

[Scientific Reports] Investigators validated a nomogram model that predicts invasive placenta in patients with placenta previa, utilizing MRI findings and clinical characteristics. A retrospective analysis was conducted on a training cohort of 269 patients from the Second Affiliated Hospital of Fujian Medical University and a validation cohort of 41 patients from Quanzhou Children’s Hospital.