Publication

[Science Advances] Scientists found that N-acetylneuraminic acid synthase mutation resulted in the absence of both sialic acid and protein polysialylation in the cortical organoids and notably reduced the proliferation and expansion of neural progenitors.

[Science Advances] Researchers reported that the Dishevelled-associated activator of morphogenesis 1 (Daam1) and its paralogue Daam2 asymmetrically regulated canonical and noncanonical Wnt signaling.

[Nature Cell Biology] The authors combined a 3D genome, RNA, accessibility and methylation sequencing method with immunoFACS and RNA sequencing in cortical organoids to map the cell-type-specific regulatory landscape of human neural development across multiple epigenetic layers.

[Gut Microbes] Investigators derived organoids from the small intestine from a cohort of healthy individuals. Culturing intestinal epithelium on a flat laminin matrix induced their differentiation, facilitating analysis of microbial responses via the apical membrane normally exposed to the luminal content.

[Pediatric Research] Investigators evaluated the effects of an agonistic Tie2 signal on renal interstitial fibrosis and elucidated the underlying mechanisms.

[British Journal Of Cancer] Higher EEF1A2 levels in breast cancer cells enhanced cell growth, movement, blood vessel function, and tubule formation in HUVECs, as confirmed by ex-ovo and in-vivo tests.