Publication

[Journal of Biomedical Science] Investigators evaluated the impact of Nedd4 deficiency on mouse T cell development and differentiation using flow cytometry and siRNA transfection, and subsequently validated these findings in T cells from patients with multiple sclerosis.

[Cell Death & Disease] Researchers provided the first complete characterization of circulating arrhythmogenic cardiomyopathy (ACM) immune cells, revealing an abundance of Treg. The high expression of IL-32 in ACM Treg may contribute to accelerated cardiac remodeling in ACM patients’ hearts.

[Journal of Nanobiotechnology] Scientists underscored the potential of mRNA complexes for efficient mRNA delivery, eliciting effective antitumor responses and modulating the tumor microenvironment to treat peritoneal carcinomatosis.

[Molecular Metabolism] Scientists used either T cell-specific acetyl-CoA carboxylase 1 (ACC1) knockout mice or ACC1 inhibition via a pharmacological agent to examine the effects on Treg differentiation and stability.

[Journal of Neuroimmune Pharmacology] Investigators explored the effects of treadmill training on Treg upregulation and its influence on myelin repair and functional recovery in rats with middle cerebral artery occlusion

[Inflammation] Researchers assessed the frequencies of naive Tregs and memory Tregs in the peripheral blood of rheumatoid arthritis patients and to explore their relationships with cytokine levels.