Publication

[Cancer Cell] When crossed to CAG-LSL-MycT58A mice, Msi2-CreERT2 mice developed multiple pancreatic cancer subtypes: ductal, acinar, adenosquamous, and rare anaplastic tumors.

[Nature Communications] In a fecal microbiota transplantation mouse model, the colonization of gut microbiota from hypertriglyceridemic pancreatitis patients recruited neutrophils and increased neutrophil extracellular traps formation that exacerbated pancreatic injury and systemic inflammation.

[Nature Medicine] In a phase II, placebo-controlled, randomized, parallel group, double-blind trial, 96 children and adolescents with new-onset T1D received antiviral treatment with pleconaril and ribavirin or placebo for six months, with the aim of preserving β cell function.

[Nature Communications] To understand the contribution of CTCF-mediated chromatin organization to cell lineage commitment, investigators analyzed 3D chromatin architecture during the differentiation of human embryonic stem cells into pancreatic islet organoids.

[American Journal Of Transplantation] A new method was developed to permit the long-term culture of islets. Human islets were embedded in polysaccharide 3D-hydrogel in cell culture inserts or gas-permeable chambers with serum-free CMRL 1066 Supplemented media for up to eight weeks.

[ACS Nano] Researchers developed an engineering strategy to tune the therapeutic potential of extracellular vesicles using nanotopographical cues.