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T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplant for the Treatment of Fanconi Anemia and MDS/AML

[Bone Marrow Transplantation] Researchers retrospectively evaluated the outcomes of thirty patients with Fanconi anemia and myelodysplastic syndrome/AML who underwent first allogeneic hematopoietic stem cell transplantation with a T cell-depleted graft at our institution.

A Pilot Study of Cord Blood-Derived Natural Killer Cells As Maintenance Therapy After Autologous Hematopoietic Stem Cell Transplantation

[Annals Of Hematology] Investigators expanded cord blood-derived natural killer (CB-NK) cells ex vivo from random donors and investigated the feasibility and efficacy of repeated infusions CB-NK cells as maintenance therapy after autologous hematopoietic stem cell transplantation.

The Catalytic Subunit of DNA-PK Regulates Transcription and Splicing of AR in Advanced Prostate Cancer

[Journal of Clinical Investigation] Researchers demonstrated that the DNA-PK holoenzyme was part of the androgen receptor variant 7 (AR-V7) interactome and was a key regulator of AR-V-mediated transcription and cell growth in models of advanced prostate cancer.

Light-Responsive Smart Nanocarriers for Wirelessly Controlled Photodynamic Therapy for Prostate Cancers

[Acta Biomaterialia] The combination of smart nanocarrier and sequential '405-580 nm' irradiation strategy exhibited good photodynamic therapy efficacy against 2D 22RV1 prostate cancer cells as well as 3D cancer cell spheroids.

Loss of PDE4D7 Expression Promotes Androgen Independence, Neuroendocrine Differentiation, and Alterations in DNA Repair: Implications for Therapeutic Strategies

[British Journal of Cancer] Using shRNA-mediated PDE4D7 knockdown in LNCaP cells, scientists replicated clinical observations that diminished PDE4D7 expression promoted an aggressive prostate cancer phenotype.

m6A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR

[Molecular Cancer Research] Investigators found that circular RNA DDIT4 (circDDIT4) was downregulated in prostate cancer and functioned as a tumor suppressor during prostate cancer progression.

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