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Mammary Cell News
EIF4A3-Mediated circ_0042881 Activates the RAS Pathway via miR-217/SOS1 Axis to Facilitate Breast Cancer Progression
[Cell Death & Disease] The authors investigated the clinical implications and underlying mechanisms of circ_0042881 in breast cancer (BC). Functionally, circ_0042881 significantly accelerated the proliferation, migration, and invasion of BC cells in vitro and tumor growth and metastasis in vivo.
Mammary Cell News
ICAM-1-Decorated Extracellular Vesicles Loaded with miR-146a and Glut1 Drive Immunomodulation and Hinder Tumor Progression in a Murine Model of Breast Cancer
[Biomaterials Science] Investigators reported on a novel nanotechnology-based approach to target tumor-associated immune cells and promoted “anti-tumor” responses in a murine model of breast cancer.
Mammary Cell News
A Combination of a Cell Penetrating Peptide and a Protein Translation Inhibitor Kills Metastatic Breast Cancer Cells
[Cell Death Discovery] Scientists reported that Nutrient Autophagy Factor 1 was efficient in killing BT-549, Hs 578T, MDA-MB-436, and MDA-MB-453 breast cancer cells, but that MDA-MB-157 cells were resistant to it.
Mammary Cell News
DEPDC1B-Mediated USP5 Deubiquitination of β-Catenin Promotes Breast Cancer Metastasis by Activating the Wnt/β-Catenin Pathway
[American Journal Of Physiology-Cell Physiology] The authors found that DEPDC1B was highly expressed in breast cancer cells and tissues and was associated with lower overall survival in patients.
Mammary Cell News
Increased RUNX3 Expression Mediates Tumor-Promoting Ability of Human Breast Cancer-Associated Fibroblasts
[Cancer Medicine] Researchers found that the exp-cancer-associated fibroblasts highly expressed Runt-related transcription factor 3 (RUNX3), while counterpart fibroblasts did not.
Mammary Cell News
Effect of 2-Methoxyestradiol Treatment on Early- and Late-Stage Breast Cancer Progression in a Mouse Model
[Cell Biochemistry and Function] Scientists compared the effect of 2-methoxyestradiol in early- and late-stage breast cancer using a transgenic mouse model—FVB/N-Tg—of spontaneously development of aggressive mammary carcinoma with lung metastasis.