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EIF4A3-Mediated circ_0042881 Activates the RAS Pathway via miR-217/SOS1 Axis to Facilitate Breast Cancer Progression

[Cell Death & Disease] The authors investigated the clinical implications and underlying mechanisms of circ_0042881 in breast cancer (BC). Functionally, circ_0042881 significantly accelerated the proliferation, migration, and invasion of BC cells in vitro and tumor growth and metastasis in vivo.

ICAM-1-Decorated Extracellular Vesicles Loaded with miR-146a and Glut1 Drive Immunomodulation and Hinder Tumor Progression in a Murine Model of Breast Cancer

[Biomaterials Science] Investigators reported on a novel nanotechnology-based approach to target tumor-associated immune cells and promoted “anti-tumor” responses in a murine model of breast cancer.

A Combination of a Cell Penetrating Peptide and a Protein Translation Inhibitor Kills Metastatic Breast Cancer Cells

[Cell Death Discovery] Scientists reported that Nutrient Autophagy Factor 1 was efficient in killing BT-549, Hs 578T, MDA-MB-436, and MDA-MB-453 breast cancer cells, but that MDA-MB-157 cells were resistant to it.

DEPDC1B-Mediated USP5 Deubiquitination of β-Catenin Promotes Breast Cancer Metastasis by Activating the Wnt/β-Catenin Pathway

[American Journal Of Physiology-Cell Physiology] The authors found that DEPDC1B was highly expressed in breast cancer cells and tissues and was associated with lower overall survival in patients.

Increased RUNX3 Expression Mediates Tumor-Promoting Ability of Human Breast Cancer-Associated Fibroblasts

[Cancer Medicine] Researchers found that the exp-cancer-associated fibroblasts highly expressed Runt-related transcription factor 3 (RUNX3), while counterpart fibroblasts did not.

Effect of 2-Methoxyestradiol Treatment on Early- and Late-Stage Breast Cancer Progression in a Mouse Model

[Cell Biochemistry and Function] Scientists compared the effect of 2-methoxyestradiol in early- and late-stage breast cancer using a transgenic mouse model—FVB/N-Tg—of spontaneously development of aggressive mammary carcinoma with lung metastasis.

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