Publication

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators tested whether the MISTRG6 strain of humanized mice could be transplanted with healthy or scleroderma human skin grafts. They found that healthy and scleroderma skin grafts retained skin and bone marrow–derived immune cells.

[Cell Death & Disease] The authors found that N-terminal gasdermin D was aberrantly expressed in epidermis of skin lesion in psoriasis patients and imiquimod-induced psoriasis-like dermatitis mice.

[Oncogene] Researchers showed that the expression of the growth regulation by estrogen in breast cancer 1 (GREB1) splicing variant, isoform 4, was mediated by microphthalmia-associated transcription factor (MITF) in melanoma cells.

[Scientific Reports] Scientists investigated anti-atopic and anti-inflammatory activities of Sanguisorba hakusanensis ethanol extract both in vivo using NC/Nga mice and in vitro using human HaCaT keratinocytes.

[Cell Biochemistry And Function] Researchers investigated the effects of exogenous kynurenine compounds on melanoma cells in vitro. They found that the various exogenous kynurenine compounds each displayed different levels of cytotoxicity, which were cell line specific.

[Digestive Diseases And Sciences] The authors used the human hepatic stellate cell line LX-2 for in vitro assays and used TGF-β1 to induce hepatic fibrosis in LX-2 cells. They analyzed cytotoxicity using a cell-counting kit-8 and transwell chambers to detect the migratory ability of LX-2 cells.