Review

[Expert Opinion On Drug Delivery] The authors introduce the structure and composition of colonic mucus as well as its impact on the bioavailability of oral drugs. We also introduce various technologies used in the construction of mucus-penetrating nanomedicines and discuss their mechanisms and potential techniques for improving mucus penetration of nanotherapeutics.

[Nature Reviews Cancer] Recent development and approval of next-generation estrogen receptor-α (ER) antagonists to target ESR1-mutant breast cancer underscores the clinical importance of this evolvability and sets a new paradigm for the treatment of ER+ breast cancers.

[Cell Death Discovery] The authors summarize the advances and limitations of the state-of-the-art reconstruction platforms for intestinal organoids.

[Pharmacology & Therapeutics] The authors explore the role of adenosine in fibrosis and evaluates the contribution of the different adenosine receptors to fibrogenesis.

[NPJ Primary Care Respiratory Medicine] Investigators review the benefits and risks of inhaled corticosteroids use in COPD, drawing on evidence from recent randomized controlled trials and observational studies conducted in primary care.

[Chemical Society Reviews] The authors discuss the recent advances in leveraging nanoparticles to overcome four major biological barriers including the lung mucus, the gastrointestinal mucus, the placental barrier, and the blood–brain barrier.