Review

[iScience] Scientists discuss the relevance of receptor tyrosine kinases (RTK) signaling in the progression of cutaneous squamous cell carcinoma, and observations from clinical trials that used RTK inhibitors against cutaneous squamous cell carcinoma

[Cell] The authors review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia.

[Molecular Therapy Oncolytics] Scientists discuss nonimmune components and various immune cells within the tumor microenvironment and their putative roles during prostate cancer initiation, progression, and metastasis.

[Nature Reviews Immunology] The authors detail the progression of immune system and microbiota maturation in early life, highlight the mechanistic links between microbes and the immune system, and summarize the role of early-life host–microorganism interactions in allergic disease development.

[Trends In Immunology] Scientists summarize the newly emerging role of viral and host-derived RNA polymerase III transcripts in immunity, and also highlight recent advances in understanding how mammalian cells prevent unwanted immune activation by these RNAs to maintain homeostasis.

[Nature Reviews Disease Primers] To better understand the underlying mechanism and define relationships between environmental factors and young-onset-colorectal cancer development, long-term prospective studies are needed with lifestyle data collected from childhood.