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Approaches to Modeling Placental Function in Preeclampsia In Vitro and In Vivo

[Journal of Endocrinology] The authors review recent developments in stem-cell based models, organoids, and various co-culture systems which recapitulate various aspects of preeclampsia.

Injectable Hydrogels in Central Nervous System: Unique and Novel Platforms for Promoting Extracellular Matrix Remodeling and Tissue Engineering

[Materials Today Bio] Scientists discuss the pathophysiology of the central nervous system and the use of several kinds of injectable hydrogels for brain and spinal cord tissue engineering, paying particular emphasis to recent experimental studies.

Development of Substrates for the Culture of Human Pluripotent Stem Cells

[Biomaterials Science] The authors summarize the development of extracellular matrix proteins for hPSCs, which are now the mainstream alternative, and synthetic substrates that are expected to be the future mainstream alternative.

A Pluripotent Road to Immunoengineering

[Nature Reviews Bioengineering] The variability, time commitment, and cost of engineering chimeric antigen receptor-T cells limit their application. hPSCs could provide an off-the-shelf, cheaper, and scalable solution.

Genotype–Phenotype Landscapes for Immune–Pathogen Coevolution

[Trends In Immunology] The authors describe several approaches that probe different regions of the high-dimensional sequence space and comment on how combinations of these methods may offer novel insight into immune–pathogen coevolution.

Interplay between Endogenous and Exogenous Human Retroviruses

[Trends In Microbiology] Scientists review the impact of infection by exogenous retroviruses on the expression of human endogenous retroviruses (HERVs), the effect of HERVs on the pathogenicity of HIV and human T-cell lymphotropic viruses and on the severity of the diseases caused by them, and the antiviral protection that HERVs can allegedly provide to the host.

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