Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

The authors explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell]
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Tumor-Induced Neurogenesis and Immune Evasion as Targets of Innovative Anti-Cancer Therapies

The authors discuss the potential of anti-neurogenesis and, considering the interplay between nervous and immune systems, they also focus on anti-immunosuppression-based therapies.
[Signal Transduction and Targeted Therapy]
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Delivery of Oligonucleotides to the Liver with GalNAc – From Research to Registered Therapeutic Drug

Scientists highlight some of the recent chemistry and preclinical advances in this space leading to this large number of clinical candidates against a diverse range of targets in liver hepatocytes.
[Molecular Therapy]
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Cross Talk between Mesenchymal and Glioblastoma Stem Cells: Communication beyond Controversies

The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
[Stem Cells Translational Medicine]
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BRAF Mutated Colorectal Cancer: New Treatment Approaches

The authors study the biology of a subgroup of colon cancer harboring a BRAF mutation, to understand the current approach in clinical research.
[Cancers]
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Organoid Models for Mammary Gland Dynamics and Breast Cancer

The authors summarized key aspects of mammary gland biology and corresponding organoid models. The investigators also discussed emerging applications where organoids will be transformative for studying both the biology and diseases of the breast.
[Current Opinion in Cell Biology]
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Regulation of Heterogeneous Cancer-Associated Fibroblasts: The Molecular Pathology of Activated Signaling Pathways

Pro-inflammatory cytokines, such as leukemia inhibitory factor and interleukin-6, were secreted by both cancer cells and cancer associated fibroblasts (CAFs), and mediated the epigenetic modification of CAFs. This enhanced the pro-tumorigenic function of CAFs mediated by promoting actomyosin contractility and ECM remodeling to form the tracks used for collective cancer cell migration.
[Journal of Experimental & Clinical Cancer Research]
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Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

Several of the cytokines involved in COVID-19 employ a distinct intracellular signaling pathway mediated by Janus kinases (JAKs). JAK inhibition, therefore, presents an attractive therapeutic strategy for cytokine release syndrome, which is a common cause of adverse clinical outcomes in COVID-19.
[Trends in Pharmacological Sciences]
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Variations in Killer-Cell Immunoglobulin-Like Receptor and Human Leukocyte Antigen Genes and Immunity to Malaria

Understanding the role of killer-cell immunoglobulin-like receptors and human leukocyte antigens in immunity to malaria can help to better characterize antimalarial immune responses. The authors summarize the different KIRs and HLAs associated with immunity to malaria thus far.
[Cellular & Molecular Immunology]
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From Threat to Cure: Understanding of Virus-Induced Cell Death Leads to Highly Immunogenic Oncolytic Influenza Viruses

The authors discuss strategies for targeting viral replication to cancerous lesions and arming them with immunogenic transgenes. They describe which modes of cell death are induced by influenza A virus infection and how these insights may be utilized to optimize influenza A virus-based oncolytic virus design.
[Cell Death Discovery]
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Considering How Biological Sex Impacts Immune Responses and COVID-19 Outcomes

The authors discuss available sex-disaggregated epidemiological data from the COVID-19 pandemic, introduce sex-differential features of immunity and highlight potential sex differences underlying COVID-19 severity.
[Nature Reviews Immunology]
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