Review

[Nature Reviews Bioengineering] The authors present key advances in the design of nanoscale drug delivery systems, such as polymer–drug conjugates, liposomes, nanoparticles, micelles, for subcutaneous delivery.

[Tissue Engineering Part B-Reviews] Scientists summarize the advantages of three dimensionally-cultured exosomes and introduce the 3D culture system and methods of exosome isolation, providing scientific strategies for the diagnosis, treatment, and prognosis of a wide variety of diseases.

[Biomedicine & Pharmacotherapy] Investigators summarize the recent advances in miRNAs of MSC-derived exosomes (EXOs) as a treatment for retinal degeneration, discussing the strategies and methods for engineering therapeutic MSC-EXOs.

[Blood] Scientists review the mechanisms of progression focusing on the hierarchy of clonal mutation and potential roles of transcription factor alterations, splicing factor mutations, and the bone marrow environment in progression to AML.

[Pancreatology] Investigators discuss the epidemiology, pathophysiology, and clinical management of exocrine pancreatic dysfunction after acute pancreatitis while highlighting key knowledge gaps.

[Life Sciences] Hypoxia-induced necrosis and delayed revascularization attenuate organoid viability and functional capacity, alleviated by the integration of diverse cell types e.g., human amniotic epithelial cells and human umbilical vein endothelial cells to boost vascularization.