xenograft models

[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that a unique anti-human CD81 antibody (5A6) effectively halted invasion of TNBC cell lines. They demonstrated that 5A6 induced CD81 clustering at the cell membrane and implicated JAM-A protein in the ability of this antibody to inhibit tumor cell invasion and migration.

[Phytotherapy Research] Scientists identified that TSN and RGF combination synergistically inhibited the proliferation and migration of MHCC-97L cells.

[Clinical Cancer Research] Researchers evaluated the efficacy and explored the mode-of-action of the PSMA-TTC BAY 2315497, an antibody-based targeted alpha therapy, in combination with the androgen receptor inhibitor darolutamide.

[Science Advances] Researchers showed that up-regulation of hexose-6-phosphate dehydrogenase protein occured in prostate cancer tissues of men treated with enzalutamide, human-derived cell lines, and patient-derived prostate tissues treated ex vivo with enzalutamide.

[Science] Researchers established a noncanonical function for small nuclear ribonucleoprotein polypeptide A′ (SNRPA1) and a previously unknown RNA structural code that regulated alternative splicing, and found that this SNRPA1-mediated pathway acted as a promoter of breast cancer metastasis.

[Oncogene] Scientists identified serine hydroxymethyltransferase-2 (SHMT2) as a critical regulator of 5-FU chemoresistance in colorectal cancer.