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[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors determined whether TrkB signaling is required for perinatal general capillary cell proliferation and pulmonary angiogenesis in a hyperoxia mouse bronchopulmonary dysplasia model.

[American Journal of Physiology-Regulatory Integrative and Comparative Physiology] Scientists tested the hypothesis that IL-6 induced mitochondrial reactive oxygen species (ROS) production and blunted nitric oxide (NO) bioavailability in endothelial cells.

[Clinical Cancer Research] Scientists conducted a Phase I/II single institution study combining chemotherapy gemcitabine and nab-paclitaxel, CCR2/5 inhibitor BMS-813160, and nivolumab for four 28-day cycles for patients with borderline resectable or locally advanced PDAC.

[Cell] Investigators discovered that the inositol-requiring enzyme 1α (IRE1α) digestion motif was present in insulin mRNA carrying SNP rs3842752. This SNP in the 3′ untranslated region of insulin gene associated with protection from T1D.

[Autophagy] Researchers demonstrated that microplastics intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis in vitro and in vivo.

[Oncology Reports] Scientists elucidated the role and underlying mechanisms of miR‑10b‑5p in regulating necroptosis in the context of LUAD.

[Oncogene] Investigators reported the generation and characterization of a ZNF768 null mouse model. ZNF768 null mice were viable but showed a growth defect early in life.

[GSK] GSK plc announced a major new research collaboration with the UK DRI and HDR UK to advance understanding of neurodegeneration with a first-of-its-kind dementia study.

[Nature Neuroscience] Microglia respond to and modulate neuronal activity during establishment and persistence of neuropathic pain states, and microglia–neuron pathways provide targets that can be exploited to attenuate abnormal neuronal activity and provide pain relief.

[Nature Reviews Neurology] The authors provide justification, largely from preclinical mouse models but also from correlates with human tissue and biomarkers, for targeting specific complement components for therapeutic intervention in Alzheimer disease.

[Nature Neuroscience] By means of genetic capturing, activity manipulation and single-cell RNA sequencing, researchers identified distinct neural ensembles in the adult mouse spinal cord encoding mechanical and heat pain.

[Nature Communications] Scientists reported a genome-wide profiling of 5-hydroxymethylcytosine in 1079 autopsied brains of older individuals and assessed its association with multiple measures of Alzheimer’s disease pathologies.