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[Expert Review of Clinical Immunology] Scientists explore the role of Tregs in the immune system, delve into their contribution to cancer and tumor progression, and highlight therapeutic strategies targeting Tregs, along with innovative delivery systems.

[Cell Research] Researchers unveiled a mechanism for V-domain Ig suppressor of T cell activation (VISTA) regulation in T cells and highlights targeting tripartite motif containing 25 (TRIM25)–VISTA as a potential strategy to enhance tumor immunotherapy.

[Leukemia] The authors conducted integrated genome-wide CRISPR-Cas9 loss-of-function screens using CD30-specific CAR-engineered NK cells, alongside a complementary PD-L1 regulator screen, and uncovered a critical role for interleukin-1 receptor signaling in modulating CAR therapy efficacy in both ALK^⁺ and ALK^⁻ anaplastic large cell lymphoma.

[Advanced Science] Investigators employed both global and myeloid-specific conditional LIM domain only 7 (LMO7) knockout mice bearing subcutaneous tumors to investigate the role of LMO7 in regulating tumor immunity.

[Inflammation Research] Researchers described a new arthritogenic role for dual specificity phosphatase 6 (DUSP6), which is mediated by CD11b⁺ Gr1 ⁺ cells and their glycolytic activity and oxidative burst.

[Genes & Immunity] Using the ROS-deficient lupus-prone lpr mouse model, scientists employed bulk RNA sequencing, flow cytometry, and spatially resolved single-cell transcriptome imaging to comprehensively characterize tissue-resident macrophages.

[UMC Utrecht] A team investigating the pediatric inflammatory disease juvenile dermatomyositis has received a €350,000 grant for the development of a model that more accurately can predict disease progress.

[Development] Scientists found that the first definitive HSCs are marked by CD43, but not CD41, similar to the early hematopoietic progenitor cells differentiating in culture from human ES cells

[Advanced Materials] Scientists reported a neutrophil/leukemia-tropic polymersome vincristine/volasertib dual-drug nanoformulation to selectively bind to leukemia cells and neutrophils, and to ratiometrically release clinical chemotherapeutics and a polo-like kinase 1 inhibitor, thereby potentiating the treatment of AML.

[Blood] Through integrated transcriptomic, proteomic, metabolomic, phenotypic, and functional analyses of HSCs and their isolated mitochondria, scientists identified that Cx43 is present on the inner and outer mitochondrial membranes of HSCs/multipotential progenitors.

[Blood] Scientists investigated the efficacy of B-cell lymphoma 2 (BCL-2) and FMS-like tyrosine kinase 3 (FLT3) inhibition with venetoclax and gilteritinib, respectively, in preclinical models of BCL11B-a leukemia.

[Cell Death & Disease] Through integrated single-cell transcriptomic/epigenomic profiling and functional interrogation, the authors identify Setd2-mediated H3K36me3 as an indispensable epigenetic amplifier sustaining baseline inflammation in murine hematopoietic stem/progenitor cells.