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[Entos Pharmaceuticals, Inc. ] Entos Pharmaceuticals, Inc. announced a collaboration with the L-CMD Research Foundation, a nonprofit that urgently translates scientific research into treatments for LMNA-related congenital muscular dystrophy (L-CMD).

[Nature Communications] Scientists found that MARCH2 expression is significantly reduced in cardiac macrophages from doxorubicin-induced cardiomyopathy (DiCM) mice and human dilated cardiomyopathy patients.

[Advanced Healthcare Materials] The authors investigated the role of surface charge and synergistic mechano-electrical stimulation of piezoelectric poly(vinylidene fluoride) on the behaviour of H9c2 cardiac cells.

[British Journal of Cancer] Researchers investigated the role of the ALOX5 metabolism axis in doxorubicin-induced cardiomyopathy and to elucidate its underlying mechanism using genetic and pharmacological approaches.

[Cell Death & Disease] Scientists investigated the roles of DP427 and DP71 during cell proliferation and fibre differentiation. They included paralogous utrophins in our analyses, particularly the UP395 isoform, owing to its presence in muscle and its partial ability to compensate for the lack of DP427.

[Oncogene] Investigators showed that transforming growth factor β-activated kinase 1 (TAK1) expression and activity are markedly elevated in rhabdomyosarcoma cell lines and patient tumor specimens.

[Journal of Translational Medicine] Researchers revealed a novel m6A-mediated pathway that integrates biochemical (TGFβ1) and mechanical signals to direct skeletal muscle stem cells fate

[Circulation] To achieve precise manipulation of arterial smooth muscle cell (ASMCs) in vivo, researchers combined alleles for Cspg4-Dre and rox-Stop–containing Acta2-CreER, generating a mouse line with Cre activity exclusively in ASMCs.

[Nature Communications] Investigators showed that pyruvate dehydrogenase kinase 4 (PDK4), a key metabolic regulator, is upregulated in human and mouse abdominal aortic aneurysm tissues.

[Experimental Cell Research] Scientists summarize current knowledge of the molecular mechanisms underlying muscle degeneration and discusses emerging therapeutic strategies that hold promise for effective muscle regeneration.

[The University of Edinburgh] Researchers at the University of Edinburgh’s Institute of Genetics and Cancer are launching a £1.5 million Cancer Research UK-funded study to find a way to ‘trick’ bowel cancer cells.

[iScience] Using colorectal cancer cell lines, organoids, and xenograft models, investigators showed that Cya-Gly-Fer (CGF) significantly inhibits tumor growth and metastasis.