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Diltiazem Inhibits Breast Cancer Metastasis via Mediating Growth Differentiation Factor 15 and Epithelial-Mesenchymal Transition

[Oncogenesis] By using both mouse and human TNBC cell lines, investigators found that diltiazem decreased colony formation and cell migration in breast cancer cells.

A Complex Epigenome-Splicing Crosstalk Governs Epithelial-to-Mesenchymal Transition in Metastasis and Brain Development

[Nature Cell Biology] Researchers discovered that a C2H2 zinc finger protein, ZNF827, is strongly induced during various contexts of epithelial-to-mesenchymal transition (EMT), including in brain development and breast cancer metastasis.

PI3K-Activated MSC Proteomes Inhibit Mammary Tumors via Hsp90ab1 and Myh9

[Molecular Therapy Oncolytics] In an ex vivoassay, the size of freshly isolated human breast cancer tissues, including ER-positive & negative as well as HER2-positive & negative, was reduced by YS49-treated mesenchymal stem cell (MSC) derived conditioned medium.

Radiation Enhances the Efficacy of EGFR-Targeted CAR-T Cells against Triple-Negative Breast Cancer by Activating NF-κB/Icam1 Signaling

[Molecular Therapy] Mechanistically, radiation significantly increased Icam1 expression on TNBC cells via activating nuclear factor κB (NF-κB) signaling, thereby promoting chimeric antigen receptor T cell infiltration and killing.

Adipocyte Plasticity in Tissue Regeneration, Repair, and Disease

[Current Opinion in Genetics & Development] The author discusses the plasticity and function of adipocytes to tissue repair and fibrosis in four tissues: skin, heart, skeletal muscle, and mammary gland.

Propanc Biopharma Receives Notice of Allowance for Proenzyme Compositions to Treat Cancer from the European Patent Office

[Business Wire] Propanc Biopharma, Inc. today announced that a Notice of Allowance has been received from the European Patent Office for claims involving compositions of proenzymes to treat cancer.

Sanofi Trial Failure Halts Work on Breast Cancer Treatment Amcenestrant

[Reuters] Sanofi has stopped further work on amcenestrant, a treatment once seen to have strong commercial potential in breast cancer, after a second trial failure.

Upregulation of KLHL17 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer by Activating the Ras/MAPK Signaling Pathway

[Laboratory Investigation] Scientists explored the role of Kelch-like 17 (KLHL17) in the development and progression of NSCLC.

Acetate, a Gut Bacterial Product, Ameliorates Ischemia-Reperfusion Induced Acute Lung Injury in Rats

[International Immunology] Scientists examined whether short-chain fatty acids had protective effects against ischemia-reperfusion-induced acute lung injury and explored possible protective mechanisms.

Spatially Resolved Deconvolution of the Fibrotic Niche in Lung Fibrosis

[Cell Reports] Researchers confirmed findings through bioinformatic, tissue, and in vitro analyses, identifying that loss of NFKB inhibitor zeta in alveolar epithelial cells dysregulated the TGFβ/IL-6 signaling axis, which may impair homeostatic responses to environmental stress.

Cancer Cell-Derived Exosomal LINC00313 Induces M2 Macrophage Differentiation in Non-Small Cell Lung Cancer

[Clinical and Translational Oncology] The authors investigated the effect of cancer cell-derived exosomal LINC00313 on the M2 macrophage differentiation in NSCLC and clarified its underlying mechanism.

Puerarin Ameliorates Acute Lung Injury by Modulating NLRP3 Inflammasome-Induced Pyroptosis

[Cell Death Discovery] Investigators analyzed putative anti-pyroptosis effects of puerarin as mediated by the PP2A-HDAC1-NLRP3 pathway in acute lung injury.
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