Targeting the Central Nervous System in Lysosomal Storage Diseases: Strategies to Deliver Therapeutics Across the Blood-Brain Barrier

[Molecular Therapy] Researchers review the latest advancements in improving the delivery of different therapeutic agents to the central nervous system and comment upon outstanding questions in the field of neurological lysosomal storage diseases.

K27M in Canonical and Noncanonical H3 Variants Occurs in Distinct Oligodendroglial Cell Lineages in Brain Midline Gliomas

[Nature Genetics] Investigators performed an integrated analysis of 116 tumors, including single-cell transcriptome and chromatin accessibility, 3D chromatin architecture, and epigenomic profiles, and showed that K27M-mutant gliomas faithfully maintain chromatin configuration at developmental genes consistent with anatomically distinct oligodendrocyte precursor cells.

Characterization of an RNA Binding Protein Interactome Reveals a Context-Specific Post-transcriptional Landscape of Myc-Amplified Medulloblastoma

[Nature Communications] Researchers showed that the RNA-binding protein, Musashi-1 is an essential mediator of G3 medulloblastoma in both MYC-overexpressing mouse models and patient-derived xenografts.

The RNA Polymerase of Cytoplasmically Replicating Zika Virus Binds with Chromatin DNA in Nuclei and Regulates Host Gene Transcription

[Proceedings of the National Academy of Sciences of the United States of America] Scientists presented that the Zika virus, the viral RNA-dependent RNA polymerase essential for viral replication in the cytoplasm, can directly bind with chromatin DNA in the nuclei.

Piwil2 (Mili) Sustains Neurogenesis and Prevents Cellular Senescence in the Postnatal Hippocampus

[EMBO Reports] Investigators showed that Piwil2 (Mili) was essential for proper neurogenesis in the postnatal mouse hippocampus.

TRIM56 Promotes Malignant Progression of Glioblastoma by Stabilizing cIAP1 Protein

[Journal of Experimental & Clinical Cancer Research] The authors focused on TRIM56, which emerged as the most differentially expressed tripartite motif (TRIM) family member with increased expression in glioblastoma.

Mutual Regulation between Phosphofructokinase 1 Platelet Isoform and Vegf Promotes Glioblastoma Tumor Growth

[Cell Death & Disease] Scientists showed that phosphofructokinase 1 platelet isoform could promote EGFR activation-induced vascular endothelial growth factor (VEGF) expression in HIF-1α-dependent and -independent manners in glioblastoma cells.

Amelioration of Radiation-Induced Cell Death in Neuro2a Cells by Neutralizing Oxidative Stress and Reducing Mitochondrial Dysfunction Using N-Acetyl-L-Tryptophan

[Oxidative Medicine and Cellular Longevity] N-acetyl-L-tryptophan was reported for the first time as a radioprotector against ionizing radiation in neuronal cells. Scientists investigated the efficacy of N-acetyl-L-tryptophan towards ionizing radiation using Neuro2a cells.

miR-506-3p Relieves Neuropathic Pain Following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis

[Developmental Neuroscience] To investigate the function of miR-506-3p in brachial plexus avulsion-induced neuropathic pain, a total brachial plexus root avulsion model was produced in adult rats as well as IL-1β-treated motoneuron-like NSC-34 cells and the lipopolysaccharide-treated microglia cell line BV2 for in vivo and in vitro experiments, respectively.

Kaemperfol Protects Dopaminergic Neurons by Promoting mTOR-Mediated Autophagy in Parkinson’s Disease Models

[Neurochemical Research] The authors investigated whether kaempferol could protect dopaminergic neurons via autophagy and the underlying mechanisms using a MPTP/MPP+-stimulated Parkinson's disease model.

BioVie Announces Additional Findings from Phase II Alzheimer’s Disease Trial: NE3107 Appears to Impact Biomarkers of Aging-Related Disease States in Addition to Observed Reversal...

[BioVie, Inc.] BioVie Inc. announced encouraging data suggesting that NE3107 had an impact on improving patients’ DNA methylation profiles, potentially impacting biomarkers of aging-related disease states.

New U.S. Law Promises to Light Up Marijuana Research

[Science] President Joe Biden signed into law a bill that streamlined access to marijuana for medical research. The new law was expected to speed the issuance of government permits to scientists who want to study cannabis, whose medicinal promise had been widely touted but remains, with a few exceptions, unproved.