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[Cardiovascular Research] Doxorubicin (DOX) exposure induced CDK7 activation in mouse heart and isolated cardiomyocytes. Cardiac-specific ablation of cyclin-dependent kinase 7 (CDK7) attenuated DOX-induced cardiac dysfunction and fibrosis.

[Nature] Scientists generated a single-cell/single-nucleus transcriptomic and chromatin accessibility map of human limb skeletal muscles encompassing over 387,000 cells/nuclei from individuals aged 15 to 99 years with distinct fitness and frailty levels.

[Parent Project Muscular Dystrophy] Parent Project Muscular Dystrophy (PPMD) and Duchenne UK announced the recipient of their Joint Call for Therapeutic Projects. Professor Peter Kang MD, from the University of Minnesota Medical School, has been awarded the grant for his research project titled “Phase I clinical trial of myogenic progenitors for DMD.”

[JCI Insight] Researchers introduced HOSU-53, a dihydroorotate dehydrogenase inhibitor with significant monotherapy activity, which was further enhanced when combined with other standard-of-care therapeutics.

[Molecular Biology Reports] The authors utilized published single-cell RNA sequencing data from a Dux-mediated mESCs to induce a 2-cell-like transition state and selected potential drivers for the transition according to an RNA velocity analysis.

[Epigenetics & Chromatin] Chromatin organization between mESCs, newborn lens epithelium, and fiber cells were analyzed using Hi-C. Localization of CTCF in both lens chromatins was determined by ChIP-seq and compared with ESCs.

[Stem Cell Reviews And Reports] Researchers reported that human umbilical cord blood and murine bone marrow purified VSELs expressed mRNA for P1 and P2 purinergic receptors and CD39 and CD73 ectonucleotidases converting extracellular ATP into its signaling metabolite extracellular adenosine.

[Nature Communications] To identify super-enhancers driving transcription factor regulators, investigators used all-trans retinoic acid to induce neuroblastoma growth arrest and differentiation.

[Molecular Psychiatry] The authors replicated the altered corticogenesis in the Huntington’s disease (HD) fetal brain using HD patient-derived human cortical organoids.

[Aspen Neuroscience] Aspen Neuroscience, Inc. announced that the first patient has been dosed in the ASPIRO trial, a Phase I/IIa open label clinical trial to assess safety and tolerability of ANPD001.

[UC Davis Health] Researchers in the UC Davis College of Biological Sciences have received a grant to study the role of the cerebellum in autism.

[Journal of Cellular and Molecular Medicine] The authors focused on 33 genes that were regulated by m6A, m5C, or m1A (mRG), which were used to form mRG clusters and clusters of mRG differentially expressed genes clusters.