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[npj Biological Physics and Mechanics] The authors propose that Treg efficiency is shaped by cellular mechanics—particularly membrane tension and actin organization—yielding a distinct biophysical signature for antigen-specific suppression.

[Journal of Translational Medicine] The authors summarize the immunoregulatory mechanisms of CD45 across various immune cell subsets and discusses CD45-based therapeutic interventions and drug delivery strategies, bridging basic immunology with therapeutic advancement.

[American Journal of Hematology] Investigators demonstrated that disruption of inducible T cell costimulator signaling in Sanroque mice impairs Treg cell maintenance, unleashing pathogenic T cell responses.

[Science Advances] Using an in vivo CRISPR screening approach, scientists identified the ascorbate transporter Slc23a2 as a negative regulator of naive T cell activation and differentiation into effector or memory cells at steady state.

[Science Translational Medicine] Scientists conducted a controlled, Phase I/IIa trial of combined bone marrow and Treg cell therapy in HLA-mismatched living-donor kidney transplantation. This trial serves as a proof of concept for a combination cell therapy that induces chimerism-based immunomodulation in kidney transplantation without the need for irradiation.

[Journal of Controlled Release] Researchers developed FKBP12KO-Tregs using a ribonucleoprotein-based CRISPR-Cas9 approach and characterized them extensively in vitro. FKBP12KO-Tregs retain phenotype, high viability, and suppressive function comparable to unedited TregWT.

[PLoS Biology] Investigators elucidated the contribution of regulatory B cells to an allergen-encapsulating nanoparticle immunotherapy in a murine model of food allergy.

[Pharmacological Research] Scientists summarize the mechanisms by which indole-3-carboxaldehyde, a key gut microbial metabolite, acts on immune cells and discuss its implications for autoimmune disease pathogenesis.

[Immunology] Researchers investigated whether rapamycin, a well-characterized mTOR inhibitor known to favour differentiation and metabolic reprogramming of Tregs, could synergize with MOG35-55-peptide to convert naïve T cells into protective, MOG35-55-specific Tregs.

[Gut] SPP1+ macrophages established an immunosuppressive niche in colorectal cancer tumor-draining lymph nodes by promoting CD137+ Treg maturation via the SPP1-CD44-NF-κB1 axis.

[Nature] Researchers developed linafexor, a first-in-class pulsatile farnesoid X receptor (FXR) agonist that mimics natural bile acid signaling, delivering potent liver disease benefits while avoiding the toxicity associated with sustained FXR activation.

[Signal Transduction and Targeted Therapy] Using single-nucleus RNA sequencing, researchers identified significant cellular heterogeneity and a distinct hepatocyte subpopulation, termed Mallory-Denk body-associated hepatocytes.