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[Nature Communications] Researchers highlighted azoles as promising candidates for Leigh and demonstrate the potential of combining in silico screens with human brain organoids as new approach methodologies

[Nature Communications] Scientists showed that temporal and dosage-dependant modulation of retinoic acid during human retinal organoid differentiation induces distinct changes in retinal cell abundance, maturation, and organisation.

[Science Advances] Investigators described the establishment of tumor organoid (TO) and TO xenografts from patient-derived orthotopic xenografts of medulloblastoma, embryonal tumor with multilayer rosettes, and atypical teratoid rhabdoid tumors.

[Genes & Development] Using c-MYC overexpression as an initiating oncogenic event, researchers demonstrated that these lineage-restricted progenitors are susceptible to neoplastic transformation, generating tumors with group 3 medulloblastoma molecular features in vitro and in vivo.

[Journal of Translational Medicine] Investigators presented a novel strategy using an automated bioreactor platform that enables large-scale expansion of human liver organoids.

[Stem Cell Research & Therapy] Three-dimensional self-organizing kidney organoids containing nephrons and stromal cells were exposed to TGF-β1 cytokine to induce fibrotic remodeling.

[Neuro-Oncology] Scientists provide a comprehensive overview of the spectrum of glioma organoid models, recognizing that different systems offer distinct and complementary strengths, and offer practical guidance for selecting appropriate models and analytical readouts based on specific basic and translational research objectives.

[Nature Communications] Researchers used single-cell RNA-sequencing to quantify genetic contributions to cis-regulatory variation in 361,119 peripheral blood mononuclear cells of 63 acute COVID-19 patients, 39 convalescent samples, and 106 healthy controls.

[Oncogene] Researchers investigated how integrin-dependent signaling pathways regulate tumor metabolism and therapeutic vulnerability in TNBC.

[Chapman University] Dr. Kamaljit Kaur has received a $535,000 National Cancer Institute award from the National Institutes of Health..Dr. Kaur and her research team are developing novel peptide-drug conjugates designed to recognize and bind to EGFR, a protein found in elevated levels on the surface of TNBC cells.

[Cell] In a first-in-human study, researchers found that CAR-modified stem-cell memory T cells exhibited greater expansion and persistence than standard CAR T cells, enabling complete responses at low doses in the absence of lymphodepletion.

[University of Kentucky] Drs. Xia Liu and Ka Wing Fong have been awarded a combined $1.9 million from the American Cancer Society to support their respective research projects. Dr. Fong’s project targets treatment-resistant prostate cancer, and Dr. Liu’s will focus on triple-negative breast cancer, two aggressive cancer types that have few effective treatment options.