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[Nature Communications] Researchers employed cell lineage tracing, targeted cell ablation, and single-cell RNA sequencing to monitor fibroblast dynamics upon exposure to Aspergillus fumigatus in immunocompetent and immunosuppressed hosts.

[Journal of Medicinal Chemistry] Scientists reported the discovery of NP12, the first SAMHD1 degrader with intracellular activity. In a bleomycin-induced pulmonary fibrosis mouse model, NP12 delayed pulmonary fibrosis progression and exerted a protective effect on lung tissue.

[Signal Transduction and Targeted Therapy] Investigators revealed that the BMX (bone marrow tyrosine kinase on chromosome X)-E2F1 (E2F transcription factor 1) axis is a pivotal regulator of chemoresistance in small cell lung cancer.

[Cancer Research] The authors used genetically engineered organoids to identify the function of KLF5 in tumorigenesis of multiple endodermal epithelial cancers.

[Redox Biology] Researchers identified and characterized novel Stimulator of Interferon Genes (STING) agonist compounds with enhanced therapeutic potential for NSCLC.

[Cellular & Molecular Biology Letters] Investigators found that tRF3019a promoted lung adenocarcinoma progression and metastasis by stabilizing hnRNPK and enhancing hnRNPK-associated transcriptional regulation of myosin heavy chain 11 (MYH11).

[Cellular & Molecular Biology Letters] The authors explored the oncogenic role of circUBAC2 in lung adenocarcinoma (LUAD) progression and found that circUBAC2 drives LUAD progression via YAP signaling.

[International Journal of Biological Macromolecules] Scientists identify β-arrestin and receptor tyrosine kinases as crucial players in NSCLC progression, metastasis, and treatment resistance.

[Vertex Pharmaceuticals Incorporated] Vertex Pharmaceuticals Incorporated announced the US FDA has approved expanded use of ALYFTREK^® for the treatment of people with cystic fibrosis ages 6 and older with a variant in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is either responsive based on clinical and/or in vitro data or results in production of CFTR protein.

[Nature Communications] Investigators used metabolic profiling to discover that diploidization is triggered by an imbalance that arises from a smaller cytoplasmic volume and increased mitochondrial density.

[Cell Reports Methods] Researchers aimed to generate induced neural stem cells from hiPSCs having regional specification restricted to the hindbrain by upregulating hindbrain gene expression and downregulating forebrain and spinal gene expression under minimal growth factor conditions.

[Cell Proliferation] Scientists established human formative pluripotent stem cell-like cells from naïve hESCs, conventional hESCs, hiPSCs, as well as human blastocysts using the three-dimensional Matrigel culture system.