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[Circulation Research] Researchers investigated the translational potential of IL-11–regulated microRNAs as circulating biomarkers of cardiac fibrosis in patients with aortic stenosis.

[ACS Nano] Scientists proposed an ECM-biomimetic microenvironment-regulating coating, where a polyethylene glycol linker with antifouling effects is used to graft tailored recombinant humanized collagen type I possessing high cell-adhesive activity via an efficient click reaction.

[Advanced Science] Investigators showed that inhalationally delivered, lung-targeted antisense oligonucleotides against angiopoietin-like 4 attenuate both infectious and fibrotic lung disease.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers uncovered that the fibroblast growth factor receptor pathway is necessary within the neuron to initiate branching from the broken dendrite tip.

[Journal of Proteome Research] Scientists employed comparative proteomics to evaluate fibrosis induced via three CCl4 delivery methods: intraperitoneal, subcutaneous, and intragastric administration.

[Scientific Reports] To investigate the intracellular mechanisms triggered by blood components from hibernating bears, investigators treated human fibroblast cells with serum from either active bears, hibernating bears, or fetal bovine serum as controls.

[PloS One] Scientists evaluated the interleukin-13 role in liver fibrosis and develop a new predictive model that includes interleukin-13 and standard data such as age and platelet count.

[Oncogene] The authors explore the literature surrounding lipid metabolism in cancer associated fibroblasts and how this influences tumour progression and treatment resistance.

[The Journal of Immunology] Scientists review recent findings detailing the immunological functions of brain perivascular fibroblasts in the steady state and following a spectrum of pathological perturbations.

[Avalyn Pharma, Inc. (Globe Newswire)] Avalyn Pharma, Inc. announced the initiation of the AURA Phase 2 clinical trial evaluating the safety and efficacy of AP02, inhaled nintedanib administered via nebulization, in patients with idiopathic pulmonary fibrosis (IPF).

[Applied StemCell, Inc. ] Applied StemCell, Inc., announced a strategic collaboration designed to streamline and accelerate the development of iPSC-derived cell therapies.

[Cell] To accelerate drug discovery for Leigh syndrome (LS), scientists screen a library of 5,632 repurposable compounds in neural cells from LS-patient-derived iPSCs. They identified phosphodiesterase type 5 inhibitors as leads and prioritized sildenafil for its clinical safety.