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[Experimental & Molecular Medicine] Aligning therapeutic action with the intrinsic biology of myocardial healing provides a rational pathway toward more effective, durable, and biologically informed strategies for cardiac repair and, where biology permits, regeneration.

[Experimental & Molecular Medicine] Scientists investigated the contribution of EHMT2 to vascular smooth muscle cell (VSMC) proliferation, migration and neointima formation following vascular injury using carotid artery injury models and in vitro VSMC studies.

[Cell] Researchers used a combination of electron and fluorescence microscopy to demonstrate that nuclear envelope budding events occur following myoblast differentiation into myotubes and concomitant with the expression of extremely long muscle-specific transcripts.

[Science] Investigators found that microtubule dynamics could act as a toggle to direct cardiomyocyte growth. Increasing microtubule stability drove cellular widening, concomitant with redirecting mRNA export and translation along the width of the cell and reinforcement of the intercalated disc.

[Communications Biology] Scientists engineered cardiac microtissues by embedding cardiac cells in constrained collagen hydrogels, modeling aligned (anisotropic) and disorganized (isotropic) tissues. By varying tissue constraint geometry, they created conditions that either promoted or restricted anisotropy and assessed the contribution of cardiomyocyte contraction.

[Critical Path Institute^® ] Critical Path Institute® announced a $456,000 grant to Dr. James Shayman at the University of Michigan, to support development of a brain-penetrant therapy for glycosphingolipid storage disorders.

[UC News] Researchers at the University of Cincinnati (UC) Gardner Neuroscience Institute’s Brain Tumor Center have been confirmed as the first in the world to achieve complete remission of a rare pituitary cancer using a novel immunotherapy treatment.

[New York Blood Center Enterprises] The New York Blood Center Enterprises announced that they are collaborating to turn discarded cells into a library of cord blood-derived iPSCs, designed to be broadly compatible with human immune systems and available as shared research resources for regenerative medicine and cell therapy.

[Skeletal Muscle] Investigators validated a 3D culture of skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling, as compared to the traditional 2D culture, while investigating the pathophysiological mechanisms of dystrophin deficiency in vitro.

[Stem Cell Research & Therapy] Engineered hiPSC-cardiomyocyte (CM) cardiac patches, 3D constructs of hiPSC-CMs combined with supporting cells and scaffolds, represent a rapidly advancing frontier in regenerative cardiology. The authors highlight recent advances in maturation protocols, vascularization strategies, and scaffold engineering of hiPSC-CM patches.

[Skeletal Muscle] Scientists summarize the mechanosensory mechanisms through which muscle stem cells (MuSCs) respond to mechanical perturbations in regenerating myofibers. They highlight recent advances in mechanosensitive receptors, including ion channels, and the downstream mechano-signaling pathways that shape MuSC fate.

[Precision BioSciences, Inc. ] Precision BioSciences, Inc. announced the activation of the first clinical trial site and the opening of patient screening and enrollment for PBGENE-Duchenne muscular dystrophy (DMD). PBGENE-DMD, an in vivo gene editing treatment for DMD, is being evaluated in the Phase I/II FUNCTION-DMD study.