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[Nature] Scientists showed that caspase 5 (CASP5) is restricted to the human intestinal epithelium and manifests as three isoforms—CASP5A, CASP5B and CASP5C—among which CASP5C uniquely promotes Wnt signalling, which is essential for epithelial development and regeneration

[Cell Discovery] Using untargeted plasma metabolomics, researchers revealed that the level of serotonin (5-HT) is significantly elevated in gastric cancer (GC) patients. Functionally, 5-HT treatment dramatically promoted GC cell proliferation and tumor growth in a dose-dependent manner.

[Proceedings of the National Academy of Sciences of the United States of America] Using irradiation injury as a model for small intestinal epithelium injury and repair, scientists found that the intestinal microbiota accelerated epithelial restitution by amplifying a repair-associated inflammatory response that promoted the emergence of fetal-like intestinal epithelial cells, marked by Ly6a and Clu.

[Cell Death & Disease] Single-cell RNA sequencing revealed that CD8⁺ exhausted T cells were significantly enriched in adenoma and carcinoma tissues compared to adjacent normal tissues.

[Journal of Translational Medicine] Investigators elucidated the METTL3-N6-methyladenosine (m⁶A)-MALAT1-NF-κB regulatory axis in colorectal cancer, advancing the understanding of epigenetic mechanisms in cancer progression.

[Cancer Science] Researchers found that solute carrier family 1 member 3 (SLC1A3) is significantly overexpressed in colorectal cancer tissues compared to adjacent normal tissues, and elevated SLC1A3 expression is associated with poor prognosis.

[Scientific Reports] Scientists investigated the molecular mechanism by which sulfurized garlic (SAC) inhibits ferroptosis through targeting Keap1/Nrf2/GPX4 signaling pathway, thereby restoring intestinal epithelial cell barrier function and alleviating ulcerative colitis.

[Biology Direct] The authors summarize the current knowledge of alternative splicing (AS) in gastric cancer (GC). Accumulating evidence shows that aberrant AS contributes to the oncogenesis, progression, invasion, metastasis, and drug resistance of GC.

[American Gastroenterological Association] The American Gastroenterological Association (AGA) announced the selection of 84 recipients to receive $2.9 million in research funding through the annual AGA Research Foundation Awards Program.

[Nature Communications] Researchers highlighted azoles as promising candidates for Leigh and demonstrate the potential of combining in silico screens with human brain organoids as new approach methodologies

[Nature Communications] Scientists showed that temporal and dosage-dependant modulation of retinoic acid during human retinal organoid differentiation induces distinct changes in retinal cell abundance, maturation, and organisation.

[Science Advances] Investigators described the establishment of tumor organoid (TO) and TO xenografts from patient-derived orthotopic xenografts of medulloblastoma, embryonal tumor with multilayer rosettes, and atypical teratoid rhabdoid tumors.