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[Advanced Materials] A bottom-up biomaterial-based platform was introduced to program cell state changes in pancreatic cancer organoids by tuning minimal adhesion cues within a synthetic matrix.

[Cell Stem Cell] The authors demonstrated that chemical inhibition of zinc transportation boosts stem cell-derived islet organoids functional competence, offering a potential strategy to advance pre-adaptation to stress in regenerative medicine.

[Nature Communications] Researchers focused on neuronal activity in Rett syndrome patient-derived organoids, analyzing two types of MECP2 mutations—a missense mutation and a truncating mutation —using calcium imaging with three-photon microscopy.

[Cell Reports Medicine] Scientists established expandable, multi-lineage adult renal organoids directly from surgical specimens of autosomal-dominant polycystic kidney disease (ADPKD) patients and healthy donors, creating a three-dimensional high-content screening platform.

[Cell Death & Disease] Researchers developed a human induced pluripotent stem cell-derived retinal organoid model that recapitulates key aspects of age-related macular degeneration-associated photoreceptor degeneration.

[Communications Biology] Investigators developed a gravity-driven organoid perfusion platform facilitating scalable throughput and supporting drug sensitivity and toxicity assessment on organoids.

[Cell Stem Cell] With a primary emphasis on gastrointestinal malignancies, scientists outlined the capabilities and remaining limitations of organoid-based cancer models, including developmentally defined stem cell-derived systems that enable controlled early-stage modeling when premalignant material is scarce.

[Communications Biology] Scientists demonstrated that suppress of cholesterol synthases FDFT1 or SQLE enhances colorectal cancer metastasis and stemness through impairing ER stress and degrading PDIA4 or SYVN1 individually.

[Oncogene] Investigators reported that PKM2 expression is upregulated in breast CSCs (BCSCs). LINC00887 maintains the self-renewal of BCSCs by promoting PKM2 splicing and reprogramming glucose metabolism.

[NPJ Breast Cancer] Scientists investigated progesterone receptor-dependent transcriptional programs such as the unfolded protein response that can be leveraged to target CSCs in Y537S estrogen receptor gene (ESR1)-mutant breast cancer.

[Cell Death & Disease] Researchers identified a noncanonical, nuclear role of hexokinase 2 that couples systemic hyperglycemia to MYC-driven glycolysis and stemness in bladder cancer.

[Cell Death & Disease] Several new specific markers of dormant CSCs, such as p27, CD13, QSOX1, Survivin, GPD1 and BEX2, have been identified, which offer hope for targeted therapy. The authors examine recent significant findings regarding tumor stem cell dormancy in both experimental and human disease models.