Uncategorized

[Cell Reports] Researchers observed that human and rat adult cardiomyocytes cultured on stiff surfaces develop blunted insulin-mediated glucose uptake, associated with intracellular aggregation of the high-affinity glucose transporter GLUT4 within the microtubule network, and with impaired contractility.

[Science Translational Medicine] Scientists showed that Kelch repeat and BTB domain–containing 13 (KBTBD13) knockdown restores muscle function and reverses disease features in a clinically relevant mouse model of nemaline myopathy type 6, highlighting a promising therapeutic strategy.

[Stem Cell Reports] To assess the role of fibro-adipogenic progenitor (FAP)-derived insulin-like growth factor-I (IGF-I), investigators generated inducible FAP-specific Igf1-deficient mice.

[iScience] The authors found that rhabdomyosarcoma-derived cells had reduced levels of the myosin motor MYO19 and elevated levels of the dynein motor and MIRO1/2 adaptors.

[Circulation] Researchers aimed to elucidate the role of Gal-3 (galectin-3), a newly identified Ca_V1.2-binding protein, in the pathogenesis of hypertension. They identified Gal-3 as a novel binding partner and unexpected positive modulator of the Ca_V1.2 channel through binding to the intracellular II-III loop.

[American Journal of Respiratory Cell and Molecular Biology] Scientists showed that oxidized phosphatidylcholines impair airway smooth muscle β2-adrenergic receptor signaling, uncovering a potential mechanism of bronchodilator resistance in asthma.

[Journal of Physiology and Biochemistry] Investigators highlight how both mitochondrial calcium overload and deficiency disrupt skeletal muscle function, revealing distinct mechanisms and therapeutic opportunities across muscle diseases and aging.

[Satellos Bioscience, Inc.] Satellos Bioscience Inc., announced that the US FDA has granted Fast Track designation to SAT-3247 for the treatment of Duchenne. SAT-3247 is a proprietary, oral, small molecule drug candidate being developed by Satellos as a novel approach to regenerating skeletal muscle lost in Duchenne muscular dystrophy.

[Washington University in St. Louis] Nicholas O. Davidson, MD, DSc, the John E. and Adaline Simon Professor of Medicine and chief of the Division of Gastroenterology at WashU Medicine, has been named the recipient of the 2026 Distinguished Mentor Award from the American Gastroenterological Association.

[Cell Stem Cell] Researchers showed that loss of GATA6 drives lineage plasticity and fuels colorectal cancer liver metastasis by activating fetal-like and basal-like transcriptional programs.

[Nature Communications] Scientists showed, through metagenomic and metabolomic analyses of clinical cohorts, that Fusobacterium periodonticum is significantly enriched in colorectal cancer patients and strongly correlated with elevated decanoic acid levels.

[Cell Death & Disease] The authors investigated the regulatory pathway controlling MUC2 expression and O-glycosylation in colorectal cancer and assessed the therapeutic potential of rosiglitazone in restoring mucosal integrity.