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[Applied StemCell, Inc. ] Applied StemCell, Inc., announced a strategic collaboration designed to streamline and accelerate the development of iPSC-derived cell therapies.

[Cell] To accelerate drug discovery for Leigh syndrome (LS), scientists screen a library of 5,632 repurposable compounds in neural cells from LS-patient-derived iPSCs. They identified phosphodiesterase type 5 inhibitors as leads and prioritized sildenafil for its clinical safety.

[Advanced Materials] Investigators reported a customized nanoinjection strategy enabling efficient transfection of hiPSCs with various types of reporter messenger RNA.

[Nature Cell Biology] Researchers showed that a cellular quality control system called nonsense-mediated mRNA decay (NMD), which normally eliminates defective RNA molecules, plays an unexpected role in maintaining telomere integrity in pluripotent cells.

[Nature Communications] Scientists identified a previously unrecognized role of endogenous VEGF signaling in sustaining primed hESC pluripotency.

[Advanced Healthcare Materials] Researchers generated multiple hiPSC lines with inducible ETV2 expression, and subsequently differentiated them into human-induced endothelial cells, which were validated functionally and by key endothelial markers and RNA-seq analysis.

[Molecular Therapy - Nucleic Acids] In a strictly in vivo approach based on genetically engineered mouse models and single-cell RNA sequencing, scientists identified microRNA-203 (miR-203) as a critical regulator of timely progression in preimplantation mouse embryos.

[Trends In Molecular Medicine] The authors summarize genetic and chemical strategies for partial reprogramming, discuss their tissue-specific effects in vivo, and evaluate their implications for tissue regeneration and age-related disease.

[Cardiovascular Diabetology] iPSC technology offers revolutionary prospects for an autologous, limitless source of functional vascular cells, scientists summarize recent developments in differentiating iPSCs into key microvascular cell types.

[Nature Immunology] Scientists suggested a role for CD4+ T cells in enhancing immune checkpoint blocker-mediated responses in people with melanoma and mismatch-repair-deficient colon cancers that have downregulated MHC class I.

[Cell Death & Disease] Researchers investigated naive and memory CD8 T cells from healthy donors stimulated in vitro in the presence of clinically relevant JAK inhibitors targeting JAK1, JAK1/2, or JAK1/3.

[Communications Biology] Scientists discuss crosstalk between glycosylation, ubiquitination, and phosphorylation, metabolic regulation of uridine diphosphate-N-acetylglucosamine flux, and pathogen- or tumor-driven glycosylation reprogramming, highlighting glycosylation enzymes as potential immunomodulatory targets.