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[Respiratory Research] Researchers integrated single-cell transcriptomics, conditional gene knockout mouse models, organoid culture, multiplex immunofluorescence validation, and flow cytometry to investigate the role of the RS1 gene in chronic obstructive pulmonary disease.

[Transplantation] Investigators reported a novel cold storage ischemia/reperfusion injury model that incorporates physiological flow, stretch, and cell-cell interactions.

[Journal of Biochemical and Molecular Toxicology] Scientists investigated the mechanism by which BRD4 accelerates acute lung injury by promoting ferroptosis mediated by ANP32B/H3K27ac/MYC/HOXB8/BACH1 in alveolar epithelial cells.

[Nature Communications] The authors showed that HDAC4 promotes radiation resistance in lung cancer by inhibiting ferroptosis. Through a CRISPR screen in patient-derived organoids, they identified HDAC4 as a key mediator.

[Nature Communications] Using spatial histological inferences from ALK + NSCLC models, researchers showed that peristromal niches protect tumor cells from elimination, enabling in vivo persistence.

[NPJ Precision Oncology] Researchers observed that SNORD50A/B were frequently deleted in lung adenocarcinomas, and this molecular event was strongly linked to poor patient survival.

[British Journal of Cancer] Scientists identified nucleoporin 62 (NUP62) knockdown as a potential strategy to overcome osimertinib resistance in NSCLC and investigated the underlying molecular mechanisms.

[International Journal of Cancer] The authors synthesize preclinical and clinical evidence to map the interconnected lipid metabolic networks spanning tumor, immune, and stromal compartments.

[Verastem Oncology] Verastem Oncology announced that the FDA granted Fast Track Designation to VS-7375, an investigational oral KRAS G12D (ON/OFF) inhibitor, for previously treated patients with KRAS G12D-mutated advanced or metastatic NSCLC.

[ACS Nano] To modulate the oxidative microenvironment and remodel the ECM, a smart microneedle capable of regulating reactive oxygen species and delivering matrix metalloproteinase functions was developed.

[Biomaterials] The development of artificial scaffolds capable of providing dynamically evolving mineralized niches for mesenchymal stem cells remains challenging, and the underlying osteogenic mechanisms are still poorly understood. A hierarchical graphene-doped polymethyl methacrylate scaffold was fabricated via vapor-induced phase separation.

[Journal of the American Society of Nephrology] Researchers investigated the role of mesangial cell–derived ECM protein 1 in regulating mesangial matrix homeostasis and glomerular structure in mice.