Hypoxia-Induced Fascin-1 Upregulation Is Regulated by Akt/Rac1 Axis and Enhances Malignant Properties of Liver Cancer Cells via Mediating Actin Cytoskeleton Rearrangement and Hippo/Yap Activation

Researchers explored the potential functions of hypoxia-induced upregulation of Fascin-1 in liver cancer and found that Fascin-1 was upregulated by hypoxia in liver cancer cell lines, elevated in liver cancer patients and correlated with larger tumor size, lymph node metastasis, distant metastasis, and shorter overall survival.