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[Nature Medicine] Scientists performed a prespecified exploratory, longitudinal multiomic profiling of 30 people living with HIV with cancer in the Phase I CITN-12 clinical trial, in which pembrolizumab was evaluated for safety and preliminary antitumor activity. They observed an expansion of proliferating HIV-specific effector CD8+ T cells and a decline in plasma TGFβ.

[Circulation] Investigators used single-cell and bulk RNA sequencing in a murine myocardial infarction model to delineate the differentiation trajectory of Tregs from mediastinal lymph nodes to the heart.

[Blood] Scientists used TGF-β1 conditional knockout mice to specifically target platelets and megakaryocytes in a passive ITP model.

[JCI Insight] Preclinical studies in mouse models of colitis, psoriasis, and arthritis demonstrated that SIK2/SIK3 inhibition reduced inflammatory activity and promoted immunoregulatory and tolerogenic-associated pathways.

[University of Missouri] In a major leap for cancer care at the University of Missouri, the School of Medicine and MU Health Care have launched their first clinical trial using a leading-edge therapy manufactured on campus at the university’s research reactor.

[Nature] Scientists demonstrated the function of ATF6α as an endoplasmic reticulum (ER)-stress-inducing tumor driver and metabolic master regulator restricting cancer immunosurveillance for hepatocellular carcinoma, in contrast to its well-characterized role as an adaptive response to ER stress.

[Cell Death & Disease] Researchers investigated how hepatocyte ploidy affects susceptibility to acetaminophen-induced liver injury by comparing diploid-enriched liver-specific knockout of E2f7/E2f8 and polyploid-enriched control mice.

[Journal of Translational Medicine] Investigators found that EP300 is consistently upregulated in hepatocellular carcinoma and supports malignant phenotypes in vitro and in vivo.

[Journal of Medicinal Chemistry] The authors confirmed that pre-let-7-PROTACs reduce tumor stemness by degrading Lin28B, offering a promising therapeutic approach for hepatocellular carcinoma.

[Communications Biology] Researchers showed that transforming growth factor-beta-induced protein (TGFBI) promotes liver fibrosis in male C57BL/6 mice. TGFBI was upregulated in fibrotic livers and derived from non-parenchymal cells.

[Journal of Physiology and Biochemistry] Scientists uncovered how fibrosis and diabetes interact to modulate enterohepatic communication, providing insights into metabolic-associated steatotic liver disease pathophysiology and identifying potential therapeutic targets for disease management.

[Chinese Medical Journal] Scientists provide an overview of liver organoid development and discusses their applications in liver regeneration, disease modeling, drug screening, toxicity assessment, organ transplantation, and regenerative medicine.