Uncategorized

[Signal Transduction and Targeted Therapy] Investigators identified histaminylation in cardiac type I collagen isolated from mice 7 days after acute myocardial infarction by mass spectrometry.

[Journal of Clinical Investigation] Researchers studied the role of macropinocytosis in experimental pulmonary fibrosis models. They found that macropinocytosis is increased in human lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.

[Nature Communications] Scientists mapped the fibroblast transcriptional response to stretching in vivo and demonstrate that stretching forces fibroblasts to exit their quiescent state and restart proliferation.

[Nature Communications] Investigators reported that ECM immunomodulation in triple-negative breast cancer is mediated by post-translational glycan modifications on ECM proteins.

[BMC Medicine] Researchers investigated the pharmacodynamic and predictive potential of liquid, ECM-derived biomarkers reflecting cytotoxic T cell activity and fibrotic activity in patients with metastatic biliary tract cancer receiving combined immunotherapy and radiotherapy.

[Molecular Immunology] Scientists investigated fibroblast lineage progression using single-cell RNA-sequencing data from fibroblast-enriched populations in bleomycin-induced mouse models and human idiopathic pulmonary fibrosis samples.

[Seminars in Cancer Biology] The authors focus on the critical roles of ECM molecules, namely collagen, fibronectin, laminin, hyaluronic acid, galectin, and matrix metalloproteinase, in shaping the melanoma tumor immune microenvironment.

[Engitix, Ltd.] Engitix, Ltd. announced a strategic research collaboration and option agreement with GSK to identify and validate novel therapeutic targets driving liver fibrosis regression.

[UC Irvine News] University of California (UC), Irvine immunologist Lbachir BenMohamed has been awarded a $3.93 million National Institutes of Health grant to develop and test a novel therapeutic vaccine designed to prevent recurrent genital herpes.

[Cornell Chronicle] A Cornell researcher is seeking to develop a vaccine against the hepatitis C virus by harnessing the body’s natural ability to clear the infection on its own, thanks to a grant from the Pew Charitable Trusts. Dr. Andrew Flyak has been named a 2026 Pew Scholar in the Biomedical Sciences.

[Nature Nanotechnology] In mice, intranasal co-administration of NanoCF501 with an antigen comprising multivalent fragments derived from different coronaviruses induces robust mucosal and systemic immunity, conferring protection against homologous/heterologous pan-β-coronaviruses.

[BMJ-British Medical Journal] The authors explore recent advances and future directions in malaria vaccine development, highlighting the need for new approaches to achieve sustainable protection against Plasmodium species.