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[CaixaResearch Institute] Dr. Gabriel Rabinovich has been awarded the 5th FERO Dr Baselga Grant. The project will focus on pancreatic ductal adenocarcinoma and explore how the tumor microenvironment interferes with the immune system’s ability to respond effectively.

[UNK News] University of Nebraska (UNK) at Kearney associate biology professor Dr. Joe Dolence has received a National Institutes of Health grant. The grant provides $500,000 to support research examining why males and females respond differently to peanut allergens and how those differences may influence the development of peanut allergies.

[Nature Immunology] Researchers used single-cell RNA sequencing to analyze regulatory T cells (Treg) in synovial tissues from patients with rhuematoid arthiriits. They identified two predominant Treg states, CD25hiCXCR6pos Treg cells and dysfunctional CD25loAREGpos Treg cells, both enriched in synovial tissues but not in blood.

[Cancer Gene Therapy] The authors explore how TFF3 signaling contributes to tumor progression and immune escape, and how its inhibition might reshape the tumor microenvironment (TME) to better support CAR-T cell activity

[Nature Communications] Scientists profiled PBMCs from 167 healthy individuals, infants, children, adolescents, young adults, middle‑aged, older adults and oldest old using scRNA‑seq and snATAC‑seq. They provide insight into human immune system dynamics across the human lifespan, emphasizing unique features of the infant immune system.

[Journal of Clinical Investigation] Adaptive immune function declines with age through coordinated cellular and molecular programs. T and B lymphocytes exhibit a decline in naive cells, progressive loss of stemness, shortened lifespan, and constrained clonal diversity.

[EMBO Reports] Scientists described SATB Homeobox 1 (SATB1)-regulated gene signatures as largely subset-specific, with broader effects on regulatory T cells (Treg) cells. SATB1 knockout reduces suppressive capacities of human Treg cells but boosts tumor clearance via CD4 CAR T cells in a preclinical model.

[JCI Insight] Researchers investigated whether severe bronchopulmonary dysplasia and systemic infection, 2 major complications of prematurity, produce distinct immune signatures and change immune composition over time.

[Cancer Cell] Investigators described a method leveraging somatic mitochondrial DNA mutations to reconstruct clonal lineage relationships between cells in native human tissues.

[Nature Communications] Investigators showed that its major driver oncogene KRAS activates the cGAS-STING-TBK1 axis, inducing a type I interferon response that primes PDAC cells for necroptosis.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists designed a mouse model that enables pulldown of endogenous BiP selectively from β cells and reveals chaperone complexes that coordinate to limit proinsulin misfolding.

[npj Precision Oncology] Researchers identified Wolfram syndrome 1 (WFS1) as a potential molecular vulnerability in KRAS^G12D-driven PDAC. Their findings suggest that WFS1 expression is upregulated following KRAS^G12D activation and may promote tumorigenesis and metastasis.