A Synthesized Olean-28,13β-Lactam Targets YTHDF1-GLS1 Axis to Induce ROS-Dependent Metabolic Crisis and Cell Death in Pancreatic Adenocarcinoma

Researchers evaluated and confirmed the promising anti-tumor activity of olean-28,13β-lactam (B28) in vitro. RNA-seq profile indicated that multiple metabolic pathways were interrupted in B28 treated pancreatic adenocarcinoma cells.