[Bio-Techne] Bio-Techne announced that its Simple Western^™ Technology played a key role in supporting the FDA approval of ZEVASKYN^™, a novel cell-based gene therapy for patients with recessive dystrophic epidermolysis bullosa.

[Cell Proliferation] Researchers established a melasma-like model in C57BL/6J mice. Histopathological analysis revealed an accumulation of melanin granules in the epidermis and superficial dermis, elevated levels of tyrosinase in both skin and plasma, systemic oxidative stress imbalance, and reduced autophagic activity in the lesional skin.

[Physiological Reviews] The authors describe male pattern androgenetic alopecia (mpAGA) as a physiological phenomenon in which defined hair follicle populations in developmentally preprogrammed scalp skin regions undergo a dramatic, but reversible (mini-)organ transformation in genetically predisposed individuals.

[Cell Death & Disease] Researchers reported a novel long noncoding RNA, LINC00622, which modulates mTORC1-regulated autophagy in cutaneous melanoma.

[Journal of Cell Science] Scientists generated immortalized primary mouse keratinocytes inducibly expressing multiple engineered and cancer-associated mutations, including those present in non-melanoma skin cancers.

[Mesoblast (GlobeNewswire)] Mesoblast announced alignment with the US FDA on items required for filing a Biologics License Application for Revascor^{® (rexlemestrocel-L) in the treatment of patients with ischemic heart failure with reduced ejection fraction and inflammation.}

[] BriaCell Therapeutics announced updated Phase II survival data for its lead immunotherapy candidate, Bria-IMT, in combination with an immune check point inhibitor. The data showed a meaningful survival advantage in heavily pretreated metastatic breast cancer patient subtypes.

[Cell] To exploit LAG-3’s proximity to T cell receptor (TCR) and maximize LAG-3-dependent T cell suppression, scientists developed an Fc-attenuated LAG-3/TCR inhibitory bispecific antibody to bypass the requirement of cognate peptide-MHC class II.

[Nature Immunology] Researchers conducted an unbiased genome-wide CRISPR screen of primary macrophages. Their study confirmed the function of known regulators in tumor associated macrophage responses and revealed new insights into the behavior of these cells.

[Genome Biology] Scientists performed in-depth bioinformatic analysis and functional experiments for EOMES, finding that the nasopharyngeal carcinoma-risk alleles of four functional SNPs upregulate EOMES expression by promoting the activity of regulatory elements in T cells.

[Nature Immunology] The authors demonstrated that PD-1 deficiency enhances the function of T_reg cells through expression of a compensatory network of coinhibitory receptors.

[Science Translational Medicine] Scientists reported that postmortem and explanted human hypertrophic cardiomyopathy (HCM) hearts exhibited chronic focal leukocyte infiltration and prominent activation of immune cells. Gene set enrichment analysis revealed that active immune responses were present in the mid- and late-stage HCM human hearts and in mouse hearts from several HCM mouse models.