BAP1 Shapes the Bone Marrow Niche for Lymphopoiesis by Fine-Tuning Epigenetic Profiles in Endosteal Mesenchymal Stromal Cells

Investigators reported that BAP1 in bone marrow MSCs was critical for the maintenance of hematopoietic stem cells and B lymphopoiesis. Mice lacking BAP1 in MSCs showed aberrant differentiation of hematopoietic stem and progenitor cells, impaired B lymphoid differentiation, and expansion of myeloid lineages.