| Vol. 16.27 – 13 July, 2022 |
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| Knockdown of Hsa21-encoded type I interferon receptors, IFNARs, rescued the down syndrome microglial phenotypes both during brain development and in response to pathological tau. [Cell Stem Cell] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated that glioma cells could sustain growth independent of immune system constraint by reducing Notch signaling. [Developmental Cell] |
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| Investigators found that SORBS3 negatively regulated autophagy in several cell lines, including mouse primary neurons. [Autophagy] |
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| Scientists reported that infected and bystander astrocytes have a corresponding increase in inflammatory gene expression, reactivity characteristics, increased cytokine and growth factor signaling, and cellular stress. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Using explanted cultured retinae, the authors demonstrated that ectopic N-Myc induced cell cycle entry in cells expressing markers of several retinal types yet induced continuous proliferation and tumorigenesis only in cone precursors. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Using a cellular Parkinson’s Disease model, scientists demonstrated that retinoic acid-associated orphan nuclear receptor expression (RORα) was down-regulated in 1 methyl 4 phenyl pyridinium ion-treated BV2 cells but up-regulated by melatonin. [npj Parkinson’s Disease] |
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| Scientists demonstrated that blockade of RET signaling using pharmacological inhibitors and genetic knockdown enhanced signaling endosome transport in wild-type motor neurons. [Cell Death & Disease] |
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| Two human glioblastoma cell lines were examined after treatment with temozolomide, ferroptosis inducers, and ferroptosis inhibitor. [Cell Death & Disease] |
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| Recent progress in understanding histone modifications in regulating embryonic and adult neurogenesis is comprehensively reviewed. [Signal Transduction and Targeted Therapy] |
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| The authors discuss possible mechanisms and molecular functions of Long intergenic noncoding RNAs (lincRNAs) in the pathogenesis of selected autoimmune and neurodegenerative disorders. [Molecular Neurobiology] |
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| PharmaTher Holdings Ltd. announced that the US Patent and Trademark Office has provided a Notice of Allowance for patent application No. 15/574,346, which includes claims intended to cover ketamine in the potential treatment of Parkinson’s Disease and motor disorders. [PharmaTher Holdings Ltd.] |
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| October 3 – 5, 2022 Vancouver, British Columbia, Canada |
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| University of Twente – Enschede, Netherlands |
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| Delft University of Technology – Delft, Netherlands |
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| University of Rochester Medical Center – Rochester, New York, United States |
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| UF Scripps Biomedical Research – Jupiter, Florida, United States |
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| Johns Hopkins Medicine – Baltimore, Maryland, United States |
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