NewslettersESC & iPSC NewsNeural Cell NewsOrganoid NewsType-I-Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s DiseaseBy lbeveridge - July 11, 20220363Knockdown of Hsa21-encoded type I interferon receptors, IFNARs, rescued the down syndrome microglial phenotypes both during brain development and in response to pathological tau.[Cell Stem Cell]AbstractGraphical Abstract