Neural Cell News Volume 16.27 | Jul 13 2022

    By
    lbeveridge
    -
    0
    27








    2022-07-13 | NCN 16.27


    Neural Cell News by STEMCELL Technologies
    Vol. 16.27 – 13 July, 2022
    TOP STORY

    Type-I-Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s Disease

    Knockdown of Hsa21-encoded type I interferon receptors, IFNARs, rescued the down syndrome microglial phenotypes both during brain development and in response to pathological tau.
    [Cell Stem Cell]

    AbstractGraphical Abstract
    Subscribe to our immunology newsletters for a chance to win a personalized lab coat
    PUBLICATIONSRanked by the impact factor of the journal

    Interferon-γ Resistance and Immune Evasion in Glioma Develop via Notch-Regulated Co-Evolution of Malignant and Immune Cells

    Investigators demonstrated that glioma cells could sustain growth independent of immune system constraint by reducing Notch signaling.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Increased SORBS3 Expression in Brain Aging Contributes to Autophagic Decline via YAP1-WWTR1/TAZ Signaling

    Investigators found that SORBS3 negatively regulated autophagy in several cell lines, including mouse primary neurons.
    [Autophagy]

    Full Article

    Tropism of SARS-CoV-2 for Human Cortical Astrocytes

    Scientists reported that infected and bystander astrocytes have a corresponding increase in inflammatory gene expression, reactivity characteristics, increased cytokine and growth factor signaling, and cellular stress.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    An Immature, Dedifferentiated, and Lineage-Deconstrained Cone Precursor Origin of N-Myc–Initiated Retinoblastoma

    Using explanted cultured retinae, the authors demonstrated that ectopic N-Myc induced cell cycle entry in cells expressing markers of several retinal types yet induced continuous proliferation and tumorigenesis only in cone precursors.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Melatonin Ameliorates Parkinson’s Disease via Regulating Microglia Polarization in a RORα-Dependent Pathway

    Using a cellular Parkinson’s Disease model, scientists demonstrated that retinoic acid-associated orphan nuclear receptor expression (RORα) was down-regulated in 1 methyl 4 phenyl pyridinium ion-treated BV2 cells but up-regulated by melatonin.
    [npj Parkinson’s Disease]

    Full Article

    Bimodal Regulation of Axonal Transport by the GDNF-RET Signaling Axis in Healthy and Diseased Motor Neurons

    Scientists demonstrated that blockade of RET signaling using pharmacological inhibitors and genetic knockdown enhanced signaling endosome transport in wild-type motor neurons.
    [Cell Death & Disease]

    Full Article

    High Levels of NRF2 Sensitize Temozolomide-Resistant Glioblastoma Cells to Ferroptosis via ABCC1/MRP1 Upregulation

    Two human glioblastoma cell lines were examined after treatment with temozolomide, ferroptosis inducers, and ferroptosis inhibitor.
    [Cell Death & Disease]

    Full Article
    Survey results on the insights and hurdles of CRISPR genome editing.
    REVIEWS

    The Role of Histone Modifications: From Neurodevelopment to Neurodiseases

    Recent progress in understanding histone modifications in regulating embryonic and adult neurogenesis is comprehensively reviewed.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Long Intergenic Noncoding RNAs Affect Biological Pathways Underlying Autoimmune and Neurodegenerative Disorders

    The authors discuss possible mechanisms and molecular functions of Long intergenic noncoding RNAs (lincRNAs) in the pathogenesis of selected autoimmune and neurodegenerative disorders.
    [Molecular Neurobiology]

    Full Article

    INDUSTRY AND POLICY NEWS

    PharmaTher Announces Notice of Allowance for US Patent Covering Ketamine for the Potential Treatment of Parkinson’s Disease and Motor Disorders

    PharmaTher Holdings Ltd. announced that the US Patent and Trademark Office has provided a Notice of Allowance for patent application No. 15/574,346, which includes claims intended to cover ketamine in the potential treatment of Parkinson’s Disease and motor disorders.
    [PharmaTher Holdings Ltd.]

    Press Release
    FEATURED EVENT

    Till & McCulloch Meetings

    October 3 – 5, 2022
    Vancouver, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    PhD Position – Pluripotent Stem Cell-Derived Gut-Brain Axis

    University of Twente – Enschede, Netherlands

    PhD Position – Analog/Mixed-Signal IC Design

    Delft University of Technology – Delft, Netherlands

    Postdoctoral Research Fellow – Neural Stem Cells

    University of Rochester Medical Center – Rochester, New York, United States

    Faculty Position – Neuroscience

    UF Scripps Biomedical Research – Jupiter, Florida, United States

    Postdoctoral Fellow – Division of Neuropathology

    Johns Hopkins Medicine – Baltimore, Maryland, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Neural Cell News Twitter