Modulation of the Activity of Histone Lysine Methyltransferases and Demethylases by Curcumin Analog in Leukemia Cells

Scientists compared the effect of dimethoxycurcumin and curcumin on a variety of histone posttranslational modifications and on the activity of histone lysine methyltransferase and demethylase enzymes that targeted the H3K4, H3K9, and H3K27 epigenetic marks in leukemia cells.