HSPB8 Counteracts Tumor Activity of BRAF– and NRAS-Mutant Melanoma Cells by Modulation of RAS-Prenylation and Autophagy

In melanoma cell lines characterized by low HSPB8 levels, scientists demonstrated that the restoration of HSPB8 expression caused cell growth arrest, reversion of epithelial-mesenchymal transition)-like phenotype switching and antimigratory effect.