Transcriptional Programming of CD4+ TRM Differentiation in Viral Infection Balances Effector- and Memory-Associated Gene Expression

Researchers investigated the phenotypic, functional, and transcriptional profiles of CD4+ tissue resident memory T cells (TRM) in the small intestine responding to acute viral infection, revealing a shared gene expression program and chromatin accessibility profile with circulating TH1 and the progressive acquisition of a mature TRM program.