Identification of an IL-1 Receptor Mutation Driving Autoinflammation Directs IL-1-Targeted Drug Design

Mice with a homologous mutation exhibited hyperinflammation and greater susceptibility to collagen antibody-induced arthritis, accompanied with pathological osteoclastogenesis. Scientists leveraged this to design an IL-1 therapeutic, which trapped IL-1β and IL-1α, but not IL-1Ra.