Vol. 15.35 – 5 September, 2023 TOP STORY Surface-Tethered ROS-Responsive Micelle Backpacks for Boosting Mesenchymal Stem Cell Vitality and Modulating Inflammation in Ischemic Stroke Treatment Using bioorthogonal click chemistry, reactive oxygen species (ROS)-responsive luteolin-loaded micelles were tethered to the surface of MSCs. [Journal of Controlled Release] AbstractGraphical Abstract PUBLICATIONSRanked by the impact factor of the journal IN VITRO Tensin-3 Is Involved in Osteogenic versus Adipogenic Fate of Human Bone Marrow Stromal Cells Researchers linked the domain structure in tensin-3 (TNS3) to RhoA activity via actin dynamics and implicated an important role for TNS3 in regulating osteogenesis and adipogenesis from bone marrow-derived stromal cells. [Cellular and Molecular Life Sciences] Full Article Effect of the Secretome of Mesenchymal Stem Cells Overexpressing BMP-9 on Osteoblast Differentiation and Bone Repair The potential of the MSCBMP-9-secretome to induce osteoblast differentiation and bone formation shed lights on novel cell-free-based therapies to promote bone regeneration of challenging defects. [Journal of Cellular Physiology] Abstract Transcriptional Targets of TWIST1 in Human Mesenchymal Stem/Stromal Cells Mechanistically Link Stem/Progenitor and Paracrine Functions To define the full spectrum of TWIST1 activity in MSCs, the authors employed integrated omics-based profiling to identify a high confidence set of TWIST1 targets. [Stem Cells] AbstractGraphical Abstract TiO2 Nanotubes Promote Osteogenic Differentiation of Human Bone Marrow Stem Cells via Epigenetic Regulation of RMRP/DLEU2/EZH2 Pathway Scientists showed that lncRNA RMRP was upregulated by TiO2 nanotubes to promote osteogenic differentiation through DLEU2/EZH2-mediated epigenetic modifications. [Biomedical Materials] Abstract Vanadium-Doped Mesoporous Bioactive Glass Promotes Osteogenic Differentiation of rBMSCs via the WNT/β-Catenin Signaling Pathway A pentavalent vanadium-doped mesoporous bioactive glass was prepared, and its effects on osteogenic differentiation of rat bone marrow MSCs and potential signaling pathways were investigated. [ACS Applied Bio Materials] AbstractGraphical Abstract IN VIVO Local Transplantation of Mesenchymal Stem Cells Improves Encephalo-Myo-Synangiosis-Mediated Collateral Neovascularization in Chronic Brain Ischemia Investigators explored whether local transplantation of MSCs in temporal muscle could promote collateral angiogenesis. [Stem Cell Research & Therapy] Full Article Mesenchymal Stem Cells Promote Polarization of M2 Macrophages in Mice with Acute-on-Chronic Liver Failure via Mertk/JAK1/STAT6 Signaling Mouse bone marrow-derived MSCs were used to treat an acute-on-chronic liver failure mouse model or cocultured with RAW264.7/J774A.1 macrophages that were stimulated with LPS. [Stem Cells] AbstractGraphical Abstract Total Flavonoids of Rhizoma Drynariae Improves Tendon-Bone Healing for Anterior Cruciate Ligament Reconstruction in Mice and Promotes the Osteogenic Differentiation of Bone Mesenchymal Stem Cells by the ERR1/2-Gga1-TGF-β/MAPK Pathway Total flavonoids of Rhizoma drynariae improved tendon-bone healing in anterior cruciate ligament reconstruction mouse models and facilitated the osteogenic differentiation of bone MSCs through the ERR1/2-Gga1-TGF-β/MAPK pathway. [Environmental Toxicology] Abstract REVIEWS Mesenchymal Stem/Stromal Cell-Based Cell-Free Therapy for the Treatment of Acute Lung Injury Scientists review MSCs and their therapeutic potential in various diseases, including acute lung injury. They also consider the potential of MSC-based cell-free therapy for future clinical treatment. [Journal of Cellular Biochemistry] Abstract INDUSTRY AND POLICY NEWS Stem Cells Used to Successfully Treat Arthritis in Gorilla at Budapest Zoo Professor Kiss-Tóth and Professor Wilkinson are now jointly leading a preclinical program to test Stem CellX technologies for the development of a similar stem cell treatment in human patients. [University of Sheffield] Press Release FEATURED EVENT AACR Special Conference: Ovarian Cancer October 5 – 7, 2023 Boston, Massachusetts, United States > See All Events JOB OPPORTUNITIES Laboratory Research Scientist – Human Normal and Leukemic Stem Cells Francis Crick Institute – London, England, United Kingdom Research Associate – Pulmonary Research Cedars-Sinai – Los Angeles, California, United States Postdoctoral Scientist – Cancer Research Cluster Cedars-Sinai – Los Angeles, California, United States Postdoctoral Research Fellow – CDK4/6 Biology and Inhibitor Resistance Dana-Farber Cancer Institute – Boston, Massachusetts, United States Research Associate – Recombinant Protein Creative Biolabs – New York, New York, United States > See All Jobs Brought to you by Science News Mesenchymal Cell News Archives Contact Us