CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia Is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216

Investigators established CD34+ cord blood–derived CBFA2T3::GLIS2models that sustained serial transplantation and recapitulated human leukemia regarding immunophenotype, leukemia-initiating cell frequencies, comutational landscape.