Bmi1 Regulates Neural Differentiation of Mesenchymal Stem Cells through the Wnt3a‑RhoA Signaling Pathway to Repair Ischemic Brain Injury in Rats

In vitro experiments were performed using the Wnt signaling agonist Wnt3a and the B lymphoma Mo‑MLV insertion region 1 homolog (Bmi1) small molecule inhibitor PTC209 to treat MSCs, and scientists explored the roles and regulatory mechanisms of the Bmi1 and Wnt3a‑RhoA signaling pathways on the neural differentiation of MSCs.