Keep Current with the Latest in Cell Biology Research

lncRNA SNHG11 Facilitates Prostate Cancer Progression through the Upregulation of IGF-1R Expression and by Sponging miR-184

Researchers investigated the functional role and molecular mechanisms of SNHG11 in prostate cancer (PCa) progression. It was revealed that the SNHG11 expression levels were significantly upregulated in PCa tissues, in comparison with those in adjacent normal tissues.
[International Journal of Molecular Sciences]
Xie, Q., Zhao, S., Kang, R., & Wang, X. (2021). lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184. International Journal of Molecular Medicine, 48(3), 1–11. https://doi.org/10.3892/ijmm.2021.5015 Cite
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Cardiff Researcher Awarded £230K to Transform Prostate Cancer Treatment

Researchers from Cardiff University have received a grant worth over £230,000 from leading men’s health charity Prostate Cancer UK. The funding will help them develop a deeper understanding of how prostate cancer affects the immune system, so it’s clearer which men could benefit from powerful new immunotherapy treatments.
[Wales 247]
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PIWI-Interacting RNA in Cancer: Molecular Mechanisms and Possible Clinical Implications (Review)

The authors highlight the latest research progress made in the biological functions and regulation of PIWI‑interacting RNA in mammals, their involvement in various cancer forms and their potential clinical applications.
[Oncology Reports]
Yuan, C., Qin, H., Ponnusamy, M., Chen, Y., & Lin, Z. (2021). PIWI‑interacting RNA in cancer: Molecular mechanisms and possible clinical implications (Review). Oncology Reports, 46(3), 1–16. https://doi.org/10.3892/or.2021.8160 Cite
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Androgen Receptor Antagonists Produced by Streptomyces Overcome Resistance to Enzalutamide

From the natural product screening, the novel compound arabilin was isolated from Streptomyces sp. MK756-CF1. Unlike STK765173, arabilin could overcome resistance to enzalutamide.
[Journal of Antibiotics]
Imoto, M., Fujimaki, T., Saito, S., & Tashiro, E. (2021). Androgen receptor antagonists produced by Streptomyces overcome resistance to enzalutamide. The Journal of Antibiotics, 1–11. https://doi.org/10.1038/s41429-021-00453-y Cite
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Compromised Dental Cells Viability Following Teeth-Whitening Exposure

Researchers assessed the viability of dental cells following time-dependent carbamide peroxide teeth-whitening treatments using an in vitro dentin perfusion assay model.
[Scientific Reports]
Redha, O., Mazinanian, M., Nguyen, S., Son, D. O., Lodyga, M., Hinz, B., Odlyha, M., McDonald, A., & Bozec, L. (2021). Compromised dental cells viability following teeth-whitening exposure. Scientific Reports, 11(1), 15547. https://doi.org/10.1038/s41598-021-94745-w Cite
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Mkx Mediates Tenogenic Differentiation but Incompletely Inhibits the Proliferation of Hypoxic MSCs

qRT-PCR, western blot, and immunofluorescence staining were performed to evaluate the expression of Mkx and other tendon-associated markers in adipose-derived MSCs and bone marrow-derived MSCs under hypoxia condition.
[Stem Cell Research & Therapy]
Chen, G., Fan, D., Zhang, W., Wang, S., Gu, J., Gao, Y., He, L., Li, W., Zhang, C., Li, M., Zhang, Y., Liu, Z., & Hao, Q. (2021). Mkx mediates tenogenic differentiation but incompletely inhibits the proliferation of hypoxic MSCs. Stem Cell Research & Therapy, 12(1), 426. https://doi.org/10.1186/s13287-021-02506-3 Cite
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Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial

In this single-center, Phase I trial, we administered anti-CD7 chimeric antigen receptor (CAR) T cells, manufactured from either previous stem-cell transplantation donors or new donors, to patients with relapsed or refractory T-cell acute lymphoblastic leukemia, in single infusions at doses of 5 × 105 or 1 × 106 cells per kilogram of body weight.
[Journal of Clinical Oncology]
Pan, J., Tan, Y., Wang, G., Deng, B., Ling, Z., Song, W., Seery, S., Zhang, Y., Peng, S., Xu, J., Duan, J., Wang, Z., Yu, X., Zheng, Q., Xu, X., Yuan, Y., Yan, F., Tian, Z., Tang, K., … Feng, X. (2021). Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial. Journal of Clinical Oncology, JCO.21.00389. https://doi.org/10.1200/JCO.21.00389 Cite
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The Synergistic Anticancer Traits of Graphene Oxide Plus Doxorubicin Against BT474 and MCF7 Breast Cancer Stem Cells In Vitro

Different concentrations of doxorubicin (DOX), graphene oxide, and graphene oxide plus doxorubicin (GO-DOX) were subjected to MCF7 and BT474 human breast cancer cells at specified intervals.
[Applied Biochemistry and Biotechnology]
Ebrahimi, M., Teimouri, M., & Pooladi, M. (2021). The Synergistic Anticancer Traits of Graphene Oxide Plus Doxorubicin Against BT474 and MCF7 Breast Cancer Stem Cells In Vitro. Applied Biochemistry and Biotechnology. https://doi.org/10.1007/s12010-021-03623-8 Cite
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Modulation of Preeclampsia by the Cholinergic Anti-Inflammatory Pathway: Therapeutic Perspectives

Investigators summarize reports in the literature regarding the roles of peripheral and reflex cholinergic neuroinflammatory pathways of nicotinic acetylcholine receptors in reprogramming preeclampsia complications in mothers and their progenies.
[Biochemical Pharmacology]
Wedn, A. M., El-Bassossy, H. M., Eid, A. H., & El-Mas, M. M. (2021). Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives. Biochemical Pharmacology, 192, 114703. https://doi.org/10.1016/j.bcp.2021.114703 Cite
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The Role of Interleukin-1β in the Immune Response to Contact Allergens

The authors summarize the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD.
[Contact Dermatitis]
Yeung, K., Mraz, V., Geisler, C., Skov, L., & Bonefeld, C. M. (n.d.). The role of interleukin-1β in the immune response to contact allergens. Contact Dermatitis, n/a(n/a). https://doi.org/10.1111/cod.13955 Cite
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Revolo Biotherapeutics Announces Clinical Trial Authorization to Initiate Phase II Trial of ‘1104 in Allergic Disease in the UK

Revolo Biotherapeutics announced receipt of Clinical Trial Authorization by the Medicines and Healthcare Products Regulatory Agency in the UK to evaluate safety and efficacy of its first-in-class peptide for the treatment of allergic disease, ‘1104, in a Phase II allergen sensitivity study.
[Revolo Biotherapeutics]
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