Keep Current with the Latest in Cell Biology Research

Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.

Engineered CRISPR-Cas12a for Higher-Order Combinatorial Chromatin Perturbations

[Nature Biotechnology] Investigators engineered an Acidaminococcus Cas12a (AsCas12a) variant, multiplexed transcriptional interference AsCas12a, that incorporated R1226A, a mutation that stabilized the ribonucleoprotein–DNA complex via DNA nicking.

PRMT5-Mediated Methylation of STAT3 Is Required for Lung Cancer Stem Cell Maintenance and Tumor Growth

[Communications Biology] Investigators showed that PRMT5 directly methylated STAT3 and enhances its activated tyrosine phosphorylation in non-small cell lung cancer cells.

PKC-θ Is an Important Driver of Fluoride-Induced Immune Imbalance of Regulatory T Cells/Effector T Cells

Scientists explored the mechanism of fluoride interference in the immune system and also identify the key indicators of fluoride-induced immune damage. [Human Reproduction] AbstractGraphical Abstract

Bevacizumab Induces Ferroptosis and Enhances CD8+ T Cell Immune Activity in Liver Cancer via Modulating HAT1 and Increasing IL-9

Researchers investigated whether and how bevacizumab regulated ferroptosis and immune activity in liver cancer. They performed RNA-sequencing in bevacizumab-treated human liver cancer cell line...

Deletion of TECRL Promotes Skeletal Muscle Repair by Up-Regulating EGR2

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists deciphered a mechanism that enabled the proliferation and differentiation of satellite cells through the downregulation of trans-2,3-enoyl-CoA reductase like (TECRL) during muscle regeneration.

Progresses in Overcoming the Limitations of In Vitro Erythropoiesis Using Human Induced Pluripotent Stem Cells

[Stem Cell Research & Therapy] The authors provide a brief overview of erythropoiesis and examine endeavors to recapitulate erythropoiesis in vitro using various cell sources.

Enhanced Anti-Tumor Efficacy with Multi-transgene Armed Mesenchymal Stem Cells for Treating Peritoneal Carcinomatosis

[Journal of Translational Medicine] The authors evaluated the feasibility of intraperitoneal administration of non-virally engineered MSCs to co-deliver cytosine deaminase and uracil phosphoribosyl transferase/5-Flucytosine prodrug system and interferon-beta to potentially enhance the cGAS-STING signaling axis.

Smad4 Is Essential for Epiblast Scaling and Morphogenesis after Implantation, but Nonessential Prior to Implantation in Mouse

[Development] Investigators showed that, in contrast to prior reports, bone morphogenic protein signaling (SMAD1/5/9 phosphorylation) is not detectable until implantation when it is detected in the primitive endoderm – an extraembryonic lineage.

GPR160 Regulates the Self-Renewal and Pluripotency of Mouse Embryonic Stem Cells via JAK1/STAT3 Signal Pathway

[Journal of Genetics and Genomics] Scientists showed that GPR160, a class A member of G protein-coupled receptors, was dramatically downregulated concurrent with mESC differentiation into embryoid bodies in vitro.

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