[Nature Genetics] Researchers integrated single-cell transcriptomes from 218 samples covering organoids and other models of diverse endoderm-derived tissues to establish an initial version of a human endoderm-derived organoid cell atlas.

[Cell Reports Medicine] Scientists presented a pioneering approach to classifying oral cancer subtypes based on the morphology of patient-derived organoids and proposed a therapeutic strategy.

[Cell] Investigators demonstrated in mouse models that CAR T cell therapy for both central nervous system and non-CNS cancers impaire cognitive function and induced a persistent CNS immune response characterized by white matter microglial reactivity, microglial chemokine expression, and elevated cerebrospinal fluid cytokines and chemokines.

[Scientific Reports] When acute pancreatitis was induced with repeated cerulein injections, FVB/N mice had more severe pancreatic edema, higher plasma amylase levels, increased inflammatory cell infiltration, and more extensive acinar cell necrosis relative to the C57BL/6N strain.

[Cancer Cell] The authors highlight the coordination of innate and adaptive immune response/evasion during LUAD precancer evolution and suggest TIM-3 as a potential target for LUAD precancer interception.

[Journal of Cell Biology] Scientists described a novel function for the kinesin-13 member KIF2A in cytokinesis. In genome-engineered mESCs, they found that KIF2A localizes to spindle poles during metaphase and regulates spindle length in a manner consistent with its known role as a microtubule minus-end depolymerase.

[Clinical Cancer Research] Human HCC cell lines and xenograft models were used to explore the anti-tumor activity of sitravatinib. Subcutaneous and orthotopic immunocompetent murine HCC models were used to assess the therapeutic efficacy of sitravatinib and PD-1 blockade combination therapy.

[New England Journal of Medicine] In this phase IIb, randomized, placebo-controlled, double-blind trial, investigators assigned patients with MASH who had biopsy-confirmed compensated cirrhosis to receive subcutaneous efruxifermin or placebo.

[Aging Cell] The authors discovered key sex and regional differences in mitochondrial generation of cytotoxic reactive oxygen species and their implications for dopaminergic neuron resilience using the Drosophila model.

[Scientific Reports] A mouse model of atherosclerosis was used to observe the effect of palmitic acid on the endothelial cell-specific molecule 1 (ESM1)-angiopoietin-like 4 (ANGPTL4)-autophagy signaling axis. Scientists reported that ESM1 facilitates endothelial cell proliferation and lipids homeostasis by up-regulating autophagy through ANGPTL4.

[Experimental & Molecular Medicine] Researchers investigated the role of acetylated α-tubulin in blood–brain barrier integration after intracerebral hemorrhage.

[Nature Reviews Cardiology] The authors discuss the diversity of metabolic programmes that control endothelial cell function in the cardiovascular system and how these metabolic programmes are perturbed in different cardiovascular diseases in a disease-specific manner.