[Novocure] Novocure announced that Japan’s Ministry of Health, Labour and Welfare approved reimbursement for Optune Lua^® through the country’s National Health Insurance coverage.

[British Journal of Pharmacology] Researchers investigated an intermediate subpopulation of alveolar epithelial cells, termed “Regeneration Alveolar Epithelial cells“, which reached a peak 14 days post-injury.

[Cancer Discovery] Investigators discovered that breast cancer-derived lung metastases stimulate the proliferation of alveolar type II cells in their vicinity and reprogram them into lipid feeder cells in mice and patients using spatial analysis.

[NPJ Precision Oncology] Through integrative analysis of multimodal human data researchers demonstrated that the SP-D geneexpression is reduced to near absence in metastatic NSCLC tissue, linking its loss to metastatic progression.

[NPJ Precision Oncology] Scientists delineated the N¹-Methyladenosine ( m¹A) regulatory network in lung squamous cell carcinoma (LUSC). The dominant m¹A writer of TRMT6 emerged as the most up-regulated regulator in LUSC through a comprehensive pan-cancer analysis.

[Scientific Reports] The authors investigated how miR-320a regulates RAD51 to affect the radiosensitivity of NSCLC. miR-320a expression in NSCLC tissues and cell lines was evaluated using The Cancer Genome Atlas data and qRT-PCR.

[Scientific Reports] Researchers investigated the molecular mechanism by which propofol enhances chemosensitivity in NSCLC. In vitro experiments were performed to evaluate the effects of propofol on NSCLC cell lines and to elucidate the underlying molecular mechanisms.

[Physiological Reviews] Scientists explore the current knowledge of healthy lung aging, discuss which pathomechanisms in chronic lung disease are characterized by senescence, and summarize current target therapeutics and their impact on lung disease.

[Journal of Translational Medicine] The authors summarize the potential pathways through which lactylation promotes pulmonary fibrosisThe au, based on the current sites and roles of lactylation in epithelial cells, fibroblasts, and macrophages.

[Centauri Therapeutics Limited] Centauri Therapeutics Limited announced that the Company’s lead clinical candidate in the ABX-01 programme, CTX-187, has received Qualified Infectious Disease Product designation from the US FDA.

[Cocrystal Pharma, Inc.] Cocrystal Pharma, Inc. announced the first subjects have been dosed in a Phase Ib norovirus challenge study to evaluate CDI-988, a direct-acting, oral antiviral, as both a preventive and treatment for norovirus infections.

[Nature] To understand the basis and impact of imprinting by influenza A viruses, scientists characterized the B cell responses of young children after consecutive first infections with divergent H1N1 and H3N2 strains of influenza.