[Nature Communications] Researchers used single-cell RNA-sequencing to quantify genetic contributions to cis-regulatory variation in 361,119 peripheral blood mononuclear cells of 63 acute COVID-19 patients, 39 convalescent samples, and 106 healthy controls.

[Oncogene] Researchers investigated how integrin-dependent signaling pathways regulate tumor metabolism and therapeutic vulnerability in TNBC.

[Chapman University] Dr. Kamaljit Kaur has received a $535,000 National Cancer Institute award from the National Institutes of Health..Dr. Kaur and her research team are developing novel peptide-drug conjugates designed to recognize and bind to EGFR, a protein found in elevated levels on the surface of TNBC cells.

[Cell] In a first-in-human study, researchers found that CAR-modified stem-cell memory T cells exhibited greater expansion and persistence than standard CAR T cells, enabling complete responses at low doses in the absence of lymphodepletion.

[University of Kentucky] Drs. Xia Liu and Ka Wing Fong have been awarded a combined $1.9 million from the American Cancer Society to support their respective research projects. Dr. Fong’s project targets treatment-resistant prostate cancer, and Dr. Liu’s will focus on triple-negative breast cancer, two aggressive cancer types that have few effective treatment options.

[UCLA Health] Dr. Dennis Slamon has been elected to the Association of American Physicians. Dr. Slamon is widely recognized for his pioneering work in breast cancer research and treatment, including his groundbreaking discovery of the HER2 gene’s role in aggressive forms of breast cancer

[CytoDyn, Inc.] CytoDyn, Inc. announced the successful enrollment and initial dosing of the first participant in its Expanded Access Program (EAP) for patients with TNBC. The EAP is designed to provide eligible patients who have exhausted available treatment options access to leronlimab outside of a clinical study setting.

[Cell Death & Disease] Scientists revealed that ablation of inner mitochondrial membrane protein (IMMT), a key architectural component of mitochondrial cristae, induces concurrent mitochondrial and endoplasmic reticulum stress, which selectively activates the ATF6-mediated unfolded protein response to drive breast cancer cell proliferation.

[Journal of Neuroscience] Cell therapies using derivatives of PSCs have emerged as promising approaches at restoring brain and spinal cord integrity, driving innovation from primary tissue transplants to the engineering of iPSC-derived neuronal and glial progenitors and now to complex multicellular brain and spinal cord organoids.

[Cell Reports Medicine] Scientists used in vitro phage display to generate fully human B7-H3-specific single-chain variable fragment for CAR design. In pancreatic cancer, neuroblastoma, and glioblastoma xenograft models, CAR T cells incorporating the lead human binder Y111 were well tolerated.

[Molecular Cancer Therapeutics] Researchers investigated mechanisms by which Semaphorin 7a promotes resistance to endocrine therapy and its potential as a therapeutic target for ER+ breast cancer.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators focused on the combination of mild calorie restriction (CR) and voluntary exercise as coadjuvants to chemotherapy in the treatment of TNBC using a mouse model. In this model, voluntary exercise did not add benefits beyond chemotherapy plus CR in terms of primary tumor size, body composition, or physical performance.