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Britya Ghosh
Hematopoiesis News
CD19 CAR T-cells for Pediatric Relapsed Acute Lymphoblastic Leukemia with Active CNS Involvement: A Retrospective International Study
Investigators reported an international study of fifty-five children and adolescents who received CAR T-cell therapy for relapsed B-cell precursor acute lymphoblastic leukemia with central nervous system involvement at the time of...
Hematopoiesis News
Leukotrienes Promote Stem Cell Self-Renewal and Chemoresistance in Acute Myeloid Leukemia
Scientists identified resistance genes to induction therapy in acute myeloid leukemia and elucidated ALOX5 as a novel mediator of resistance to anthracycline-based therapy.
[Leukemia] Abstract
Hematopoiesis News
Impact of CDC Warning on Co-Prescribing of Opioids and Benzodiazepines in Older Allogeneic Hematopoietic Cell Transplant Recipients
Scientists evaluated the use of opioids and/or benzodiazepines in older vs. younger allogeneic-hematopoietic cell transplant recipients before and after the CDC guidelines.
[Bone Marrow Transplantation] Abstract
Hematopoiesis News
Acute Type Adult T-cell Leukemia Cells Proliferate in the Lymph Nodes Rather Than in Peripheral Blood
Scientists reveal that lymph nodes-adult T-cell leukemia (ATL) cells display higher expression of the Ki-67 antigen than peripheral blood-ATL cells in acute type patients.
[Cancer Gene Therapy] Abstract
Hematopoiesis News
Comparative Analysis of Decitabine Intensified BUCY2 and BUCY2 Conditioning Regimen for High-Risk MDS Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Researchers retrospectively evaluated 93 consecutive high-risk myelodysplastic syndrome patients undergoing allo-hematopoietic stem cell transplantation in our institution, comparing discrepancies in clinical characteristics and outcomes between cases using Dec-intensified BUCY2 and traditional...
Hematopoiesis News
Allogeneic Hematopoietic Cell Transplantation in Patients with Therapy-Related Myeloid Neoplasm after Breast Cancer: A Study of the Chronic Malignancies Working Party of the EBMT
Researchers performed a registry study on therapy-related myeloid neoplasm, both therapy-related myelodysplastic syndrome and acute myeloid leukemia following treatment for breast cancer who underwent a first allogeneic hematopoietic cell transplant.
[Bone Marrow...
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Glutamine-Mediated Epigenetic Regulation of cFLIP Underlies Resistance to TRAIL in Pancreatic Cancer
[Experimental & Molecular Medicine] Investigators demonstrated that glutamine endowed PDAC cells with resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through KDM4C-mediated epigenetic regulation of cFLIP.
CARM1 Hypermethylates the NuRD Chromatin Remodeling Complex to Promote Cell Cycle Gene Expression and Breast Cancer Development
[Nucleic Acids Research] Scientists revealed a gene activation program that required arginine methylation established by coactivator-associated arginine methyltransferase 1 (CARM1) on a key chromatin remodeler.
PARKIN is Not Required to Sustain OXPHOS Function in Adult Mammalian Tissues
[npj Parkinson's Disease] Researchers investigated the mitochondrial role of PARKIN during aging and in response to stress by employing a series of conditional Parkin knockout mice.