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Britya Ghosh

CD19 CAR T-cells for Pediatric Relapsed Acute Lymphoblastic Leukemia with Active CNS Involvement: A Retrospective International Study

Investigators reported an international study of fifty-five children and adolescents who received CAR T-cell therapy for relapsed B-cell precursor acute lymphoblastic leukemia with central nervous system involvement at the time of...

Leukotrienes Promote Stem Cell Self-Renewal and Chemoresistance in Acute Myeloid Leukemia

Scientists identified resistance genes to induction therapy in acute myeloid leukemia and elucidated ALOX5 as a novel mediator of resistance to anthracycline-based therapy. [Leukemia] Abstract

Impact of CDC Warning on Co-Prescribing of Opioids and Benzodiazepines in Older Allogeneic Hematopoietic Cell Transplant Recipients

Scientists evaluated the use of opioids and/or benzodiazepines in older vs. younger allogeneic-hematopoietic cell transplant recipients before and after the CDC guidelines. [Bone Marrow Transplantation] Abstract

Acute Type Adult T-cell Leukemia Cells Proliferate in the Lymph Nodes Rather Than in Peripheral Blood

Scientists reveal that lymph nodes-adult T-cell leukemia (ATL) cells display higher expression of the Ki-67 antigen than peripheral blood-ATL cells in acute type patients. [Cancer Gene Therapy] Abstract

Comparative Analysis of Decitabine Intensified BUCY2 and BUCY2 Conditioning Regimen for High-Risk MDS Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Researchers retrospectively evaluated 93 consecutive high-risk myelodysplastic syndrome patients undergoing allo-hematopoietic stem cell transplantation in our institution, comparing discrepancies in clinical characteristics and outcomes between cases using Dec-intensified BUCY2 and traditional...

Allogeneic Hematopoietic Cell Transplantation in Patients with Therapy-Related Myeloid Neoplasm after Breast Cancer: A Study of the Chronic Malignancies Working Party of the EBMT

Researchers performed a registry study on therapy-related myeloid neoplasm, both therapy-related myelodysplastic syndrome and acute myeloid leukemia following treatment for breast cancer who underwent a first allogeneic hematopoietic cell transplant. [Bone Marrow...

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Glutamine-Mediated Epigenetic Regulation of cFLIP Underlies Resistance to TRAIL in Pancreatic Cancer

[Experimental & Molecular Medicine] Investigators demonstrated that glutamine endowed PDAC cells with resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through KDM4C-mediated epigenetic regulation of cFLIP.

CARM1 Hypermethylates the NuRD Chromatin Remodeling Complex to Promote Cell Cycle Gene Expression and Breast Cancer Development

[Nucleic Acids Research] Scientists revealed a gene activation program that required arginine methylation established by coactivator-associated arginine methyltransferase 1 (CARM1) on a key chromatin remodeler.

PARKIN is Not Required to Sustain OXPHOS Function in Adult Mammalian Tissues

[npj Parkinson's Disease] Researchers investigated the mitochondrial role of PARKIN during aging and in response to stress by employing a series of conditional Parkin knockout mice.