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Britya Ghosh
Endothelial Cell News
Non-Coding RNA Regulatory Networks in Post-Transcriptional Regulation of VEGFA in Cancer
The discuss the recent progress on the ncRNA-related networks controlling vascular endothelial growth factor A (VEGF-A) expression in cancer cells and provides insights into the complexity of VEGF-A post-transcriptional regulation.
[IUBMB Life] Abstract
Endothelial Cell News
Amneal Achieves Second US Biosimilars Approval with ALYMSYS® (Bevacizumab-Maly)
Amneal Pharmaceuticals, Inc. announced that the US FDA has approved the Company’s Biologics License Application for bevacizumab-maly, a biosimilar referencing Avastin®.
[Amneal Pharmaceuticals, Inc.] Press Release
Cancer Stem Cell News
Exosomal miR-4466 from Nicotine-Activated Neutrophils Promotes Tumor Cell Stemness and Metabolism in Lung Cancer Metastasis
Scientists examined the mechanism by which nicotine promotes lung cancer brain metastasis. They conducted a retrospective analysis of 810 lung cancer patients with smoking history and assessed brain metastasis.
[Oncogene] Full Article
Cancer Stem Cell News
Targeting DRD2 by the Antipsychotic Drug, Penfluridol, Retards Growth of Renal Cell Carcinoma via Inducing Stemness Inhibition and Autophagy-Mediated Apoptosis
Researchers uncovered penfluridol suppressed in vitro cell growth and in vivo tumorigenicity of various renal cell carcinoma cell lines and enhanced the Sutent-triggered growth inhibition on clear cell renal cell...
Cancer Stem Cell News
Tumor Stem Cell-Derived Exosomal microRNA-17-5p Inhibits Anti-tumor Immunity in Colorectal Cancer via Targeting SPOP and Overexpressing PD-L1
Investigators explored the effect of colorectal cancer (CRC) stem cells-derived exosomes conveying miR-17-5p on CRC.
[Cell Death Discovery] Full Article
Hematopoiesis News
Inotuzumab Ozogamicin as Single Agent in Pediatric Patients with Relapsed and Refractory Acute Lymphoblastic Leukemia: Results from a Phase II Trial
Thirty-two patients were enrolled, 28 were treated, 27 were evaluable for response. The estimated overall response rate was 81.5%, and 81.8% of the responding subjects were minimal residual disease negative.
[Leukemia] Abstract
Popular
Glutamine-Mediated Epigenetic Regulation of cFLIP Underlies Resistance to TRAIL in Pancreatic Cancer
[Experimental & Molecular Medicine] Investigators demonstrated that glutamine endowed PDAC cells with resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through KDM4C-mediated epigenetic regulation of cFLIP.
CARM1 Hypermethylates the NuRD Chromatin Remodeling Complex to Promote Cell Cycle Gene Expression and Breast Cancer Development
[Nucleic Acids Research] Scientists revealed a gene activation program that required arginine methylation established by coactivator-associated arginine methyltransferase 1 (CARM1) on a key chromatin remodeler.
PARKIN is Not Required to Sustain OXPHOS Function in Adult Mammalian Tissues
[npj Parkinson's Disease] Researchers investigated the mitochondrial role of PARKIN during aging and in response to stress by employing a series of conditional Parkin knockout mice.